ArticleHistochemistry and cell biology2005
Distribution of P2Y2 receptors in the guinea pig enteric nervous system and its coexistence with P2X2 and P2X3 receptors, neuropeptide Y, nitric oxide synthase and calretinin.
Article in Histochemistry and cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Purinergic P2YPurinergic signalling · 2025Article
- Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor.World journal of gastroenterology · 2021Review
- Expression of P2X receptors in the rat anterior pituitary.Purinergic signalling · 2020Article
- Blockage of the P2X7 Receptor Attenuates Harmful Changes Produced by Ischemia and Reperfusion in the Myenteric Plexus.Digestive diseases and sciences · 2019Article
- Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human.Purinergic signalling · 2018Article
- P2Y1, P2Y2, and TRPV1 Receptors Are Increased in Diarrhea-Predominant Irritable Bowel Syndrome and P2Y2 Correlates with Abdominal Pain.Digestive diseases and sciences · 2016Article
- Neuroimmunomodulation in the Gut: Focus on Inflammatory Bowel Disease.Mediators of inflammation · 2016Review
- The Effect of Ischemia and Reperfusion on Enteric Glial Cells and Contractile Activity in the Ileum.Digestive diseases and sciences · 2015Article
- Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons.Histochemistry and cell biology · 2015Article
- Expression of the P2Y2 receptor in the terminal rectum of fetal rats with anorectal malformation.International journal of clinical and experimental medicine · 2015Article
- Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob).World journal of gastroenterology · 2014Article
- Expression of P2X3 and P2X 5 myenteric receptors varies during the intestinal postnatal development in the guinea pig.Cellular and molecular neurobiology · 2014Article
- Purinergic signalling in the gastrointestinal tract and related organs in health and disease.Purinergic signalling · 2014Review
- Effects of ischemia and reperfusion on subpopulations of rat enteric neurons expressing the P2X7 receptor.Digestive diseases and sciences · 2013Article
- Effects of ischemia and reperfusion on P2X2 receptor expressing neurons of the rat ileum enteric nervous system.Digestive diseases and sciences · 2011Article
- Expression of P2Y receptors in the rat anterior pituitary.Purinergic signalling · 2011Article
- Effects of protein deprivation and re-feeding on P2X2 receptors in enteric neurons.World journal of gastroenterology · 2010Article
- New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC.Inflammatory bowel diseases · 2009Article
- P2X receptors are differentially expressed on vasopressin- and oxytocin-containing neurons in the supraoptic and paraventricular nuclei of rat hypothalamus.Histochemistry and cell biology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The distribution of P2Y2 receptor-immunoreactive (ir) neurons and fibers and coexistence of P2Y2 with P2X2 and P2X3 receptors, neuropeptide Y (NPY), calretinin (CR), calbindin (CB) and nitric oxide synthase (NOS) was investigated with immunostaining methods. The results showed that P2Y2-ir neurons and fibers were distributed widely in myenteric and submucous plexuses of the guinea pig stomach corpus, jejunum, ileum and colon. The typical morphology of P2Y2-ir neurons was a long process with strong positive staining on the same side of the cell body. The P2Y2-ir neurons could be Dogiel type 1. About 40-60% P2X3-ir neurons were immunoreactive for P2Y2 in the myenteric plexus and all the P2X3-ir neurons expressed the P2Y2 receptor in the submucosal plexus; almost all the NPY-ir neurons and the majority of CR-ir neurons were also immunoreactive for P2Y2, especially in the myenteric plexus of the small intestine; no P2Y2-ir neurons were immunoreactive for P2X2 receptors, CB and NOS. It is shown for the first time that S type/Dogiel type 1 neurons with fast P2X and slow P2Y receptor-mediated depolarizations could be those neurons expressing both P2Y2-ir and P2X3-ir and that they are widely distributed in myenteric and submucosal plexuses of guinea pig gut.
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Registered trials
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