Evidence map›Paper›PMID 16136049›Full record

ArticleBritish journal of cancer2005

Joint Nordic prospective study on human herpesvirus 8 and multiple myeloma risk.

R Tedeschi, T Luostarinen, P De Paoli, R E Gislefoss, L Tenkanen, J Virtamo, P Koskela, G Hallmans, M Lehtinen, J Dillner

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Epidemiologic overview of malignant lymphoma.The Korean journal of hematology · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

R TedeschiDepartment of Microbiology-Immunology and Virology, Centro di Riferimento Oncologico, Aviano, Italy.
T Luostarinen
P De Paoli
R E Gislefoss
L Tenkanen
J Virtamo
P Koskela
G Hallmans
M Lehtinen
J Dillner
Centro di Riferimento Oncologico · ITFinnish Cancer Registry · FIInstitute for Molecular Medicine Finland · FILund University · SEMed-Storm Innovation (Norway) · NOUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An association between human herpesvirus 8 (HHV8) and multiple myeloma (MM) has been reported, though most studies have not confirmed such association. To follow-up on a previous prospective seroepidemiological study, where HHV8 tended to associate with MM risk, we linked five large serum banks in the Nordic countries with the Nordic cancer registries and 329 prospectively occurring cases of MM were identified, together with 1631 control subjects matched by age and gender. The HHV8 seroprevalences among cases and controls were similar (12 and 15%, respectively) and HHV8 seropositivity did not associate with the risk of MM, neither when considering positivity for lytic antibodies (relative risk (RR) = 0.8, 95% confidence interval (CI) = 0.5-1.1) nor for latent antibodies (RR = 0.6, 95% CI = 0.1-2.7). Similar risks were seen when analysis was restricted to case-control sets with at least 2 years lag before diagnosis (RR = 0.8, 95% CI = 0.5-1.2 and RR = 0.9, 95% CI = 0.1-4.2). In conclusion, the data indicate that HHV8 infection is not associated with MM.

Indexed as

Antibodies, ViralCase-Control StudiesCohort StudiesFemaleFinlandHerpesvirus 8, HumanHumansImmunoglobulin GMaleMultiple MyelomaNorwayRisk FactorsAntibodies, ViralImmunoglobulin G

Identifiers

PMID16136049
PMCPMC2361639
OpenAlexW2149899341

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.