ArticleMolecular and cellular biology2005
Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.
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Who cites it
99 citing papers in PubMed, 183 citations in OpenAlex.
- β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.Cell metabolism · 2014Trial
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- A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat.PLoS genetics · 2025Article
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- Activation of GPR81 by lactate drives tumour-induced cachexia.Nature metabolism · 2024Article
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- Latest advances in the regulatory genes of adipocyte thermogenesis.Frontiers in endocrinology · 2023Review
- Cooling down with Entresto. Can sacubitril/valsartan combination enhance browning more than coldness?Diabetology & metabolic syndrome · 2022Review
- NFIA determines theiScience · 2022Article
- Dihydromyricetin ameliorates diet-induced obesity and promotes browning of white adipose tissue by upregulating IRF4/PGC-1α.Nutrition & metabolism · 2022Article
- NNMT is induced dynamically during beige adipogenesis in adipose tissues depot-specific manner.Journal of physiology and biochemistry · 2022Article
- Ciliary control of adipocyte progenitor cell fate regulates energy storage.Frontiers in cell and developmental biology · 2022Review
- LncRNA Ctcflos orchestrates transcription and alternative splicing in thermogenic adipogenesis.EMBO reports · 2021Article
- Plasticity and heterogeneity of thermogenic adipose tissue.Nature metabolism · 2021Review
- Browning of White Adipose Tissue as a Therapeutic Tool in the Fight against Atherosclerosis.Metabolites · 2021Review
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- Developmental and functional heterogeneity of thermogenic adipose tissue.Journal of molecular cell biology · 2020Review
- Thermogenic adipocytes: lineage, function and therapeutic potential.The Biochemical journal · 2020Review
- HYPOTHesizing about central comBAT against obesity.Journal of physiology and biochemistry · 2020Review
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Induction of brown adipocytes in white fat depots by adrenergic stimulation is a complex genetic trait in mice that affects the ability of the animal to regulate body weight. An 80-fold difference in expression of the mitochondrial uncoupling gene (Ucp1) at the mRNA and protein levels between A/J and C57BL/6J (B6) mice is controlled by allelic interactions among nine quantitative trait loci (QTLs) on eight chromosomes. Overlapping patterns of these QTLs also regulate expression levels of Pgc-1alpha, Pparalpha, and type 2 deiodinase. Independent validation that PPARalpha is associated with Ucp1 induction was obtained by treating mice with the PPARalpha agonist clofibrate, but not from the analysis of PPARalpha knockout mice. The most upstream sites of regulation for Ucp1 that differed between A/J and B6 were the phosphorylation of p38 mitogen-activated protein kinase and CREB and then followed by downstream changes in levels of mRNA for PPARgamma, PPARalpha, PGC-1alpha, and type 2 deiodinase. However, compared to Ucp1 expression, the two- to fourfold differences in the expression of these regulatory components are very modest. It is proposed that small variations in the levels of several transcriptional components of the Ucp1 enhanceosome interact synergistically to achieve large differences in Ucp1 expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.