ArticleMolecular and cellular biology2005
p73 Interacts with human immunodeficiency virus type 1 Tat in astrocytic cells and prevents its acetylation on lysine 28.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3).The Journal of biological chemistry · 2019Article
- The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders.Frontiers in microbiology · 2015Review
- Roles and functions of HIV-1 Tat protein in the CNS: an overview.Virology journal · 2013Review
- Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein.Cell cycle (Georgetown, Tex.) · 2013Article
- High-performance capillary electrophoresis for determining HIV-1 Tat protein in neurons.PloS one · 2011Article
- Transcriptional regulation of HIV-1 gene expression by p53.Cell cycle (Georgetown, Tex.) · 2010Article
- Modulation of JC virus transcription by C/EBPbeta.Virus research · 2009Article
- Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs.Nature reviews. Microbiology · 2009Review
- Evidence for modulation of BAG3 by polyomavirus JC early protein.The Journal of general virology · 2009Article
- HIV-1 Vpr deregulates calcium secretion in neural cells.Brain research · 2009Article
- HIV-1 Tat C-terminus is cleaved by calpain 1: implication for Tat-mediated neurotoxicity.Biochimica et biophysica acta · 2009Article
- Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.American journal of translational research · 2009Article
- Involvement of the p53 and p73 transcription factors in neuroAIDS.Cell cycle (Georgetown, Tex.) · 2008Article
- Early growth response-1 protein is induced by JC virus infection and binds and regulates the JC virus promoter.Virology · 2008Article
- Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin.Oncogene · 2008Article
- Tubulin-mediated binding of human immunodeficiency virus-1 Tat to the cytoskeleton causes proteasomal-dependent degradation of microtubule-associated protein 2 and neuronal damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human immunodeficiency virus type 1 (HIV-1) Tat is a potent transcriptional activator of the HIV-1 promoter and also has the ability to modulate a number of cellular regulatory circuits including apoptosis. Tat exerts its effects through interaction with viral as well as cellular proteins. Here, we studied the influence of p73, a protein that is implicated in apoptosis and cell cycle control, on Tat functions in the central nervous system. Protein interaction studies using immunoprecipitation followed by Western blot and glutathione S-transferase pull-down assays demonstrated the association of Tat with p73. Tat bound to the N-terminal region of p73 spanning amino acids 1 to 120, and this interaction required the cysteine-rich domain (amino acids 30 to 40) of Tat. Association of p73 with Tat prevented the acetylation of Tat on lysine 28 by PCAF. Functional studies including RNA interference showed that p73 inhibited Tat stimulation of the HIV-1 promoter. Furthermore, p73 prevented the interaction of Tat with cyclin T1 in vitro but not in vivo. These findings suggest possible new therapeutic approaches, using p73, for Tat-mediated AIDS pathogenesis.
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