ArticleMolecular and cellular biology2005
A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.
Article in Molecular and cellular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Twenty years of t-loops: A case study for the importance of collaboration in molecular biology.DNA repair · 2020Review
- Functional duplication of Rap1 in methylotrophic yeasts.Scientific reports · 2019Article
- Mild Telomere Dysfunction as a Force for Altering the Adaptive Potential of Subtelomeric Genes.Genetics · 2018Article
- The mechanisms of K. lactis Cdc13 in telomere DNA-binding and telomerase regulation.DNA repair · 2018Article
- Telomere recombination pathways: tales of several unhappy marriages.Current genetics · 2017Review
- Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.Nucleic acids research · 2017Article
- The many facets of homologous recombination at telomeres.Microbial cell (Graz, Austria) · 2015Review
- Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevity.PLoS genetics · 2015Article
- "Poisoning" yeast telomeres distinguishes between redundant telomere capping pathways.Chromosoma · 2012Article
- Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Molecular and cellular biology · 2012Article
- Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scrambling.PLoS genetics · 2012Article
- Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity.Eukaryotic cell · 2011Article
- Recombination can cause telomere elongations as well as truncations deep within telomeres in wild-type Kluyveromyces lactis cells.Eukaryotic cell · 2011Article
- Telomeric recombination induced by dysfunctional telomeres.Molecular biology of the cell · 2011Article
- Telomeric circles are abundant in the stn1-M1 mutant that maintains its telomeres through recombination.Nucleic acids research · 2010Article
- Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres.Genes & development · 2009Article
- Conserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotes.Molecular cell · 2009Article
- Mutant telomeric repeats in yeast can disrupt the negative regulation of recombination-mediated telomere maintenance and create an alternative lengthening of telomeres-like phenotype.Molecular and cellular biology · 2009Article
- Telomerase- and Rad52-independent immortalization of budding yeast by an inherited-long-telomere pathway of telomeric repeat amplification.Molecular and cellular biology · 2009Article
- STN1 protects chromosome ends in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Some human cancer cells achieve immortalization by using a recombinational mechanism termed ALT (alternative lengthening of telomeres). A characteristic feature of ALT cells is the presence of extremely long and heterogeneous telomeres. The molecular mechanism triggering and maintaining this pathway is currently unknown. In Kluyveromyces lactis, we have identified a novel allele of the STN1 gene that produces a runaway ALT-like telomeric phenotype by recombination despite the presence of an active telomerase pathway. Additionally, stn1-M1 cells are synthetically lethal in combination with rad52 and display chronic growth and telomere capping defects including extensive 3' single-stranded telomere DNA and highly elevated subtelomere gene conversion. Strikingly, stn1-M1 cells undergo a very high rate of telomere rapid deletion (TRD) upon reintroduction of STN1. Our results suggest that the protein encoded by STN1, which protects the terminal 3' telomere DNA, can regulate both ALT and TRD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.