ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Paired motor neuron-muscle recordings in zebrafish test the receptor blockade model for shaping synaptic current.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Zebrafish fast muscle contractions avoid the mammalian requirement for voltage-gated Na+ channels.PLoS biology · 2025Article
- Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission.iScience · 2024Article
- Lowered GnT-I Activity Decreases Complex-Type N-Glycan Amounts and Results in an Aberrant Primary Motor Neuron Structure in the Spinal Cord.Journal of developmental biology · 2024Article
- Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons.Nature communications · 2024Article
- CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Zebrafish neuromuscular junction: The power of N.Neuroscience letters · 2019Review
- Targeted mutagenesis of the ryanodine receptor by Platinum TALENs causes slow swimming behaviour in Pacific bluefin tuna (Thunnus orientalis).Scientific reports · 2019Article
- Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities.Molecular neurodegeneration · 2019Article
- Expressing acetylcholine receptors after innervation suppresses spontaneous vesicle release and causes muscle fatigue.Scientific reports · 2017Article
- Zebrafish In Situ Spinal Cord Preparation for Electrophysiological Recordings from Spinal Sensory and Motor Neurons.Journal of visualized experiments : JoVE · 2017Article
- A Gradient in Synaptic Strength and Plasticity among Motoneurons Provides a Peripheral Mechanism for Locomotor Control.Current biology : CB · 2017Article
- Fatigue in Rapsyn-Deficient Zebrafish Reflects Defective Transmitter Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Nonequivalent release sites govern synaptic depression.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Function Over Form: Modeling Groups of Inherited Neurological Conditions in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- Electrical synaptic transmission in developing zebrafish: properties and molecular composition of gap junctions at a central auditory synapse.Journal of neurophysiology · 2014Article
- Article
- Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Spinocerebellar ataxia type 13 mutation that is associated with disease onset in infancy disrupts axonal pathfinding during neuronal development.Disease models & mechanisms · 2012Article
- Zebrafish model for congenital myasthenic syndrome reveals mechanisms causal to developmental recovery.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The transparent spinal cord and electrically compact fast muscle of zebrafish offer the first opportunity to perform simultaneous whole-cell patch-clamp recordings from both motor neuron and target skeletal muscle in situ. Our paired recordings reveal the fastest reported kinetics for both spontaneous and evoked synaptic currents at any synapse and a large quantal size that facilitates the resolution of spontaneous synaptic currents. We used this preparation to test the recent proposal that open channel block of the acetylcholine receptor by acetylcholine modulates the kinetics and timing of transmission between nerve and muscle in larval zebrafish (Legendre et al., 2000). Contrary to the predictions of this model, we find similar delay and onset kinetics of synaptic current at positive and negative muscle membrane potentials, even after inhibition of acetylcholinesterase. In contrast, blockade of motor neuron K channels by 4-aminopyridine prolonged the action potential and introduced a significant delay and slowing of evoked synaptic currents, demonstrating our ability to measured altered transmitter release with this system. We conclude that the kinetics of neuromuscular synaptic currents in zebrafish is not governed by receptor block.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.