ArticleJournal of clinical immunology2005
Deficiency of somatic hypermutation of immunoglobulin G transcripts is a better predictor of severe respiratory tract infections than lack of memory B cells in common variable immunodeficiency.
Article in Journal of clinical immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Somatic Hypermutation Defects in Common Variable Immune Deficiency.Current allergy and asthma reports · 2017Review
- Evidence of perturbed germinal center dynamics, but preserved antibody diversity, in end-stage renal disease.Immunity, inflammation and disease · 2016Article
- Long-term follow-up on affinity maturation and memory B-cell generation in patients with common variable immunodeficiency.Journal of clinical immunology · 2013Article
- Expression of activation-induced cytidine deaminase gene in B lymphocytes of patients with common variable immunodeficiency.Iranian journal of pediatrics · 2013Article
- New frontiers of primary antibody deficiencies.Cellular and molecular life sciences : CMLS · 2012Review
- Altered spectrum of somatic hypermutation in common variable immunodeficiency disease characteristic of defective repair of mutations.Immunogenetics · 2011Article
- Role of B cells in common variable immune deficiency.Expert review of clinical immunology · 2009Article
- Memory B cells in common variable immunodeficiency: clinical associations and sex differences.Clinical immunology (Orlando, Fla.) · 2008Article
- Genetic defects in common variable immunodeficiency.International journal of immunogenetics · 2007Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defects of memory B cells and of somatic hypermutation (SHM) are involved in the pathogenesis of common variable immunodeficiency (CVID). Here we report for the first time a systematic study of the relationship between memory B cell deficiency and SHM abnormalities in CVID, and relate these variables to prediagnostic infections. Isotype switched Vh3-23 transcripts were undetectable or low in 30% (IgG) and 63% (IgA) of the patients, but never in controls (P < 0.001). When measurable, the SHM fraction of transcripts was significantly lower in patients (IgM: median 32% vs. 56% (P = 0.0002); IgG: 72% vs. 87% (P = 0.0002); IgA: 81% vs. 88% (P = 0.04)). The concentration of switched (CD19+/CD27+/IgG+) and unswitched (CD19+/CD27+/IgM+/IgD+) memory cells was reduced in 75% and 58% of the patients, respectively. Patients with reduced concentrations of switched memory B cells had normal or low SHM, and only the IgG SHM fraction correlated with prediagnostic incidence of severe respiratory tract infections (P = 0.004).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.