ArticleDigestive diseases and sciences2005
Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study.Journal of gastroenterology · 2011Trial
- Cell-free probiotic supernatant (CFS) treatment alleviates indomethacin-induced enterocolopathy in BALB/c mice by down-modulating inflammatory response and oxidative stress: potential alternative targeted treatment.Inflammopharmacology · 2022Article
- Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention.Nutrients · 2019Review
- The microbiota-derived metabolite indole decreases mucosal inflammation and injury in a murine model of NSAID enteropathy.Gut microbes · 2016Article
- Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure.World journal of gastroenterology · 2015Article
- Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats.Journal of physiology and biochemistry · 2013Article
- Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.Journal of neuroinflammation · 2012Article
- The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release.Brain, behavior, and immunity · 2009Article
- 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats.Digestive diseases and sciences · 2008Article
- Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.Digestive diseases and sciences · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
TNF-alpha, including other proinflammatory cytokines alone or in combination, induces iNOS expression and upregulates inflammatory responses. We evaluated the relationship between TNF-alpha and iNOS expression in indomethacin-induced jejunoileitis in male Sprague-Dawley rats. Rats were fed a daily dose of a phosphodiesterase inhibitor-either theophylline or pentoxifylline-for 2 days. Jejunoileitis was induced with two subcutaneous injections of indomethacin (7.5 mg/kg) 24 hr apart and theophylline or pentoxifylline continued for 12 hr or 4 days. Other rats received a single intraperitoneal injection of anti-TNF-alpha monoclonal antibody (TNF-Ab) 30-min before indomethacin. At 4 days TNF-Ab, theophylline, or pentoxifylline treatment significantly decreased indomethacin-induced ulceration, myeloperoxidase activity, and disease activity index. Although indomethacin significantly increased serum TNF-alpha and nitrate/nitrite levels over the control value as early as 12 hr, iNOS expression was detected only after 4 days. Serum IL-1beta level did not change at 12 hr but increased fourfold at 4 days. Treatment with TNF-Ab, theophylline, or pentoxifylline significantly reduced serum/tissue TNF-alpha, IL-1beta, nitrate/nitrite, and iNOS expression. The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression.
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