ArticleJournal of thrombosis and thrombolysis2005
The role of exercise on platelet aggregation in patients with stable coronary artery disease: exercise induces aspirin resistant platelet activation.
Article in Journal of thrombosis and thrombolysis, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- Influence of cardiopulmonary exercise test on platelet function in patients with coronary artery diseases on antiplatelet therapy.BMC cardiovascular disorders · 2022Trial
- Effect of high dose statin therapy on platelet function; statins reduce aspirin-resistant platelet aggregation in patients with coronary heart disease.Journal of thrombosis and thrombolysis · 2009Trial
- The role of aspirin resistance on outcome in patients with acute coronary syndrome and the effect of clopidogrel therapy in the prevention of major cardiovascular events.Journal of thrombosis and thrombolysis · 2006Trial
- Does Exercise Influence the Susceptibility to Arterial Thrombosis? An Integrative Perspective.Frontiers in physiology · 2021Review
- Increased exercise-related platelet activation assessed by impedance aggregometry in diabetic patients despite aspirin therapy.Journal of thrombosis and thrombolysis · 2019Article
- Relationship between endothelial functions and acetylsalicylic acid resistance in newly diagnosed hypertensive patients.Clinical cardiology · 2012Article
- Thrombosis, physical activity, and acute coronary syndromes.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Antiplatelet resistance in stroke.Expert review of neurotherapeutics · 2011Review
- Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implications.Journal of thrombosis and thrombolysis · 2010Article
- Antiplatelet Resistance-Does it Exist and How to Measure it?Clinical medicine. Cardiology · 2009Article
- Aspirin resistance: an update.Current atherosclerosis reports · 2009Review
- A review of aspirin resistance; definition, possible mechanisms, detection with platelet function tests, and its clinical outcomes.Journal of thrombosis and thrombolysis · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of our study was to determine the relation between exercise stress test and aspirin resistance in patients with stable coronary artery disease.
backgroundClinically aspirin resistance is defined as having thrombotic and embolic cardiovascular events despite regular aspirin therapy.
methodsWe studied platelet functions of 62 patients with stable coronary artery disease and 20 subjects with normal coronary arteries by Platelet Function Analyzer (PFA-100, Dade Behring, Germany) at rest and after exertion with collagen and/or epinephrine (Col/Epi) and collagen and/or ADP cartridges. Closure time (CT)<186 seconds was defined as aspirin resistance with Col/Epi cartridges of PFA-100. Symptom limited treadmill stress test (protocol of Bruce) was performed with Oxford Streslink TD-1 system.
results8 (12.9%) patients were aspirin resistant by PFA-100 (CT<186s despite regular aspirin therapy) at rest. At the first minute of the recovery period of exercise stress test 14 (22.5%) patients were aspirin resistant by PFA-100. CTs with Col/ADP were respectively 89+/-6 s (83--100s) and 89+/-5 s (82--104s) at rest and after exercise (p=0.107). 20.3% (11/54) of patients known as in vitro aspirin sensitives at rest had shorter CTs and 11.1% (6/54) had aspirin resistance after exercise (p=0.004). There was no statistically significiant difference in platelet functions in the control group after exertion.
conclusionWe conclude that 11.1% of in vitro aspirin sensitive subjects at rest had aspirin resistance after exercise by PFA-100. In some individuals, exercise induced platelet activation is aspirin insensitive at usual antiplatelet doses. We need further clinical trials to optimize antiplatelet therapy in patients with coronary artery disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.