ReviewEuropean journal of clinical pharmacology2005
Analysis of rapid heart rate variability in the assessment of anticholinergic drug effects in humans.
Review in European journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- The effect of oxybutynin on cardiac autonomic modulation in healthy subjects.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Trial
- The effect of tolterodine 4 and 8 mg on the heart rate variability in healthy subjects.World journal of urology · 2010Trial
- Dialectical behavior therapy in autistic adults: effects on ecological subjective and physiological measures of emotion dysregulation.Borderline personality disorder and emotion dysregulation · 2025Article
- Childhood Family Stress and Women's Health: Parasympathetic Activity as a Risk and Resiliency Factor.Applied psychophysiology and biofeedback · 2024Article
- Exhausted Heart Rate Responses to Repeated Psychological Stress in Women With Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Test-Retest Reliability of Pediatric Heart Rate Variability: A Meta-Analysis.Journal of psychophysiology · 2017Article
- Hidden Signals-The History and Methods of Heart Rate Variability.Frontiers in public health · 2017Review
- Central Anticholinergic Adverse Effects and Their Measurement.Drugs & aging · 2015Article
- Application of heart-rate variability in patients undergoing weaning from mechanical ventilation.Critical care (London, England) · 2014Observational
- Association between heart rate variability and fluctuations in resting-state functional connectivity.NeuroImage · 2013Article
- Cardiac effects of muscarinic receptor antagonists used for voiding dysfunction.British journal of clinical pharmacology · 2011Review
- Autonomic modulation and health-related quality of life among schizophrenic patients treated with non-intensive case management.PloS one · 2011Article
- Sex differences in short-term heart rate variability in patients with newly diagnosed essential hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2008Article
- Impaired heart rate variability and altered cardiac sympathovagal balance after antidepressant overdose.European journal of clinical pharmacology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anticholinergic agents have widespread therapeutic indications in clinical medicine. In addition, certain other drug groups-such as neuroleptics, antidepressants and antihistamines-possess distinct anticholinergic properties that reduce tolerance and compliance. Especially in patients with heart disease, attention should be paid to cardiac anticholinergic drug effects. The analysis of short-term heart rate variability (HRV) provides a noninvasive tool to estimate vagal cholinergic outflow. In this review article, we present the basic principles of the most relevant techniques to study rapid HRV: the time domain analysis methods RMSSD and pNN50, and the high-frequency (HF) spectral component of HRV. We provide examples of previously reported effects of anticholinergic agents on these measures and also describe how adrenergic drugs may influence them. We have the following recommendations for a clinical pharmacologist investigating anticholinergic agents. (1) If the breathing rate of the study subject can be controlled during the assessment and the electrocardiogram recordings contain good-quality, stationary segments that are at least a few minutes long, then the HF power of HRV should be the method of choice. (2) During uncontrolled conditions, RMSSD should be included in the analyses, because it is less affected by changes in the respiratory pattern and it can be measured from shorter segments of electrocardiogram data. (3) Reduced short-term HRV suggests an anticholinergic, but not necessarily an antimuscarinic drug effect, since the inhibition of cholinergic vagal efferent activity may also originate from central or peripheral adrenergic influences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.