ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2005
A dye mixture (Neurobiotin and Alexa 488) reveals extensive dye-coupling among neurons in leeches; physiology confirms the connections.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Article
- Innexin expression and localization in the Drosophila antenna indicate gap junction or hemichannel involvement in antennal chemosensory sensilla.Cell and tissue research · 2024Article
- Intersegmental Interactions Give Rise to a Global Network.Frontiers in neural circuits · 2022Article
- Anatomy and activity patterns in a multifunctional motor neuron and its surrounding circuits.eLife · 2021Article
- Neuroanatomical tract-tracing techniques that did go viral.Brain structure & function · 2020Review
- Acute control of the sleep switch ineLife · 2018Article
- Verifying, Challenging, and Discovering New Synapses Among Fully EM-Reconstructed Neurons in the Leech Ganglion.Frontiers in neuroanatomy · 2018Article
- Higher Network Activity Induced by Tactile Compared to Electrical Stimulation of Leech Mechanoreceptors.Frontiers in physiology · 2018Article
- Feedback Signal from Motoneurons Influences a Rhythmic Pattern Generator.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Gap junctional signaling in pattern regulation: Physiological network connectivity instructs growth and form.Developmental neurobiology · 2017Review
- Patterns and distribution of presynaptic and postsynaptic elements within serial electron microscopic reconstructions of neuronal arbors from the medicinal leech Hirudo verbana.The Journal of comparative neurology · 2016Article
- Excitatory connections of nonspiking interneurones in the terminal abdominal ganglion of the crayfish.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Gap junction-dependent homolog avoidance in the developing CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Five types of nonspiking interneurons in local pattern-generating circuits of the crayfish swimmeret system.Journal of neurophysiology · 2013Article
- Functional differentiation of a population of electrically coupled heterogeneous elements in a microcircuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Necessary, sufficient and permissive: a single locomotor command neuron important for intersegmental coordination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Cellular basis for singing motor pattern generation in the field cricket (Gryllus bimaculatus DeGeer).Brain and behavior · 2012Article
- Ectopic expression of select innexins in individual central neurons couples them to pre-existing neuronal or glial networks that express the same innexin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The activity of leech motoneurons during motor patterns is regulated by intrinsic properties and synaptic inputs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Bringing up the rear: new premotor interneurons add regional complexity to a segmentally distributed motor pattern.Journal of neurophysiology · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the neuronal circuits that generate leech movements have been studied for over 30 years, the list of interneurons (INs) in these circuits remains incomplete. Previous studies showed that some motor neurons (MNs) are electrically coupled to swim-related INs, e.g., rectifying junctions connect IN 28 to MN DI-1 (dorsal inhibitor), so we searched for additional neurons in these behavioral circuits by co-injecting Neurobiotin and Alexa Fluor 488 into segmental MNs DI-1, VI-2, DE-3 and VE-4. The high molecular weight Alexa dye is confined to the injected cell, whereas the smaller Neurobiotin molecules diffuse through gap junctions to reveal electrical coupling. We found that MNs were each dye-coupled to approximately 25 neurons, about half of which are likely to be INs. We also found that (1) dye-coupling was reliably correlated with physiologically confirmed electrical connections, (2) dye-coupling is unidirectional between MNs that are linked by rectifying connections, and (3) there are novel electrical connections between excitatory and inhibitory MNs, e.g. between excitatory MN VE-4 and inhibitory MN DI-1. The INs found in this study provide a pool of novel candidate neurons for future studies of behavioral circuits, including those underlying swimming, crawling, shortening, and bending movements.
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