ArticleImmunogenetics2005
Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Venous thromboembolism and severe COVID-19: a Mendelian randomization trial and transcriptomic analysis.Frontiers in immunology · 2024Article
- Innate immune genes of the chicken MHC and related regions.Immunogenetics · 2022Review
- The influences of microbial colonisation and germ-free status on the chicken TCRβ repertoire.Frontiers in immunology · 2022Article
- Fourth Report on Chicken Genes and Chromosomes 2022.Cytogenetic and genome research · 2022Review
- Chickens as a simple system for scientific discovery: The example of the MHC.Molecular immunology · 2021Article
- Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species.Immunogenetics · 2018Article
- The CD1 family: serving lipid antigens to T cells since the Mesozoic era.Immunogenetics · 2016Review
- Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems.Immunogenetics · 2016Review
- Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.Poultry science · 2016Review
- Analysis of the reptile CD1 genes: evolutionary implications.Immunogenetics · 2015Article
- The equine CD1 gene family is the largest and most diverse yet identified.Immunogenetics · 2014Article
- The peptide motif of the single dominantly expressed class I molecule of the chicken MHC can explain the response to a molecular defined vaccine of infectious bursal disease virus (IBDV).Immunogenetics · 2013Article
- Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals.Immunogenetics · 2013Article
- Major histocompatibility complex genomics and human disease.Annual review of genomics and human genetics · 2013Review
- Polymorphism in Exon 2 of CD1 Genes in Southwest of Iran.Iranian journal of public health · 2013Article
- Immunogenetics of the NKG2D ligand gene family.Immunogenetics · 2012Review
- Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution.Immunogenetics · 2010Article
- Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants.Molecular immunology · 2009Article
- Inhibition of CD1 antigen presentation by human cytomegalovirus.Journal of virology · 2008Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammals have several major histocompatibility complex (MHC) class-I-like genes. Although some of them are assumed to have originated before the emergence of mammals, the origin of class-I-like genes is poorly understood. We analyzed here the recently released chicken draft genome sequence and identified two families of class-I-like genes: CD1 and PROCR (the gene for the endothelial protein C receptor). Chickens have two CD1 genes, designated CD1.1 and CD1.2, located in tandem approximately 840 bp apart from each other. Chicken CD1.1 and CD1.2 are neither group 1- nor group 2-like, indicating that the two groups of CD1 emerged in a mammalian lineage. Although the database provides no information as to their chromosomal localization, we found that chicken CD1 genes are located adjacent to the previously characterized MHC B system contig on chromosome 16. We confirmed the linkage of CD1 to the B system by dual-color fluorescence in situ hybridization. Chickens have a single copy of PROCR. Among known class-I-like genes, PROCR is most closely related to CD1, indicating that CD1 and PROCR constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.