ArticleVirchows Archiv : an international journal of pathology2006
STAT 5a expression in various lesions of the breast.
Article in Virchows Archiv : an international journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- 17Journal of the Endocrine Society · 2018Article
- The prolactin receptor: Diverse and emerging roles in pathophysiology.Journal of clinical & translational endocrinology · 2015Review
- Molecular drivers of lobular carcinoma in situ.Breast cancer research : BCR · 2015Review
- Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes.Breast cancer research : BCR · 2012Article
- Cell-type-specific expression of STAT transcription factors in tissue samples from patients with lymphocytic thyroiditis.Endocrine pathology · 2012Article
- Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Article
- PTP1B suppresses prolactin activation of Stat5 in breast cancer cells.The American journal of pathology · 2010Article
- Higher expression levels of SOCS 1,3,4,7 are associated with earlier tumour stage and better clinical outcome in human breast cancer.BMC cancer · 2010Article
- Complex prolactin crosstalk in breast cancer: new therapeutic implications.Molecular and cellular endocrinology · 2009Article
- Signal transducer and activator of transcription 5A/B in prostate and breast cancers.Endocrine-related cancer · 2008Review
- Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression.Journal of mammary gland biology and neoplasia · 2008Review
- Article
- Reversed Expression of the JAK/STAT Pathway Related Proteins Prolactin Receptor and STAT5a in Normal and Abnormal Breast Epithelial Cells.Breast cancer : basic and clinical research · 2008Article
- Favorable prognostic value of SOCS2 and IGF-I in breast cancer.BMC cancer · 2007Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The seven signal transducer and activator of transcription (STAT) molecules are effectors of hormonal or cytokine stimulation through receptors. STAT 5a, isolated from prolactin-stimulated mammary cells, contributes to normal proliferation and is essential for mammary gland differentiation. Using a monoclonal antibody, we tested 100 formalin-fixed, paraffin-embedded breast tissues representing everything from simple hyperplasia to invasive carcinoma for the expression of STAT 5a in comparison to normal breast epithelial cells. Immunohistochemical analysis was performed following heat treatment in a pressure cooker. STAT 5a was found in endothelial cells, adipocytes, and leukocytes as well as in the cytoplasm and nucleus of normal epithelial cells, usual ductal hyperplasia, and benign lesions such as fibroadenoma. Myoepithelial cells and stromal fibroblasts failed to demonstrate any STAT 5a in addition to most atypical proliferations including in situ and invasive carcinomas. A few examples of lobular intraepithelial neoplasia and invasive carcinoma demonstrated some reactivity, albeit comparatively reduced. The absence of STAT 5a in the abnormal breast epithelial cells may indicate a defect contributory to the abnormal state.
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