ReviewChromosoma2005
Artificial and engineered chromosomes: developments and prospects for gene therapy.
Review in Chromosoma, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- B chromosomes put the 'super' in supernumerary.Trends in genetics : TIG · 2026Review
- Gene expressing human artificial chromosome vectors: Advantages and challenges for gene therapy.Experimental cell research · 2020Review
- De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Developing de novo human artificial chromosomes in embryonic stem cells using HSV-1 amplicon technology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Article
- Comparative study of artificial chromosome centromeres in human and murine cells.European journal of human genetics : EJHG · 2013Article
- De novo generation of plant centromeres at tandem repeats.Chromosoma · 2013Article
- Organization of synthetic alphoid DNA array in human artificial chromosome (HAC) with a conditional centromere.ACS synthetic biology · 2012Article
- Telomere length homeostasis and telomere position effect on a linear human artificial chromosome are dictated by the genetic background.Nucleic acids research · 2012Article
- Telomere-mediated truncation of barley chromosomes.Chromosoma · 2012Article
- Human artificial chromosome (HAC) vector with a conditional centromere for correction of genetic deficiencies in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy.Genetics research international · 2011Article
- Human artificial chromosome with a conditional centromere for gene delivery and gene expression.DNA research : an international journal for rapid publication of reports on genes and genomes · 2010Article
- Manipulating transgenes using a chromosome vector.Nucleic acids research · 2009Article
- HAC stability in murine cells is influenced by nuclear localization and chromatin organization.BMC cell biology · 2009Article
- Interspecific transfer of mammalian artificial chromosomes between farm animals.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Article
- Engineered plant minichromosomes: a bottom-up success?The Plant cell · 2008Article
- A novel human artificial chromosome gene expression system using herpes simplex virus type 1 vectors.EMBO reports · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
At the gene therapy session of the ICCXV Chromosome Conference (2004), recent advances in the construction of engineered chromosomes and de novo human artificial chromosomes were presented. The long-term aims of these studies are to develop vectors as tools for studying genome and chromosome function and for delivering genes into cells for therapeutic applications. There are two primary advantages of chromosome-based vector systems over most conventional vectors for gene delivery. First, the transferred DNA can be stably maintained without the risks associated with insertion, and second, large DNA segments encompassing genes and their regulatory elements can be introduced, leading to more reliable transgene expression. There is clearly a need for safe and effective gene transfer vectors to correct genetic defects. Among the topics discussed at the gene therapy session and the main focus of this review are requirements for de novo human artificial chromosome formation, assembly of chromatin on de novo human artificial chromosomes, advances in vector construction, and chromosome transfer to cells and animals.
Indexed as
Identifiers
16133351What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.