Trial reportChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2005
Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma.
Trial report in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Global pediatric craniopharyngioma management modalities and outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Pooled it
- Intracystic bleomycin for cystic craniopharyngiomas in children.The Cochrane database of systematic reviews · 2016Pooled it
- A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Pooled it
- Phase II study of peginterferon alpha-2b for patients with unresectable or recurrent craniopharyngiomas: a Pediatric Brain Tumor Consortium report.Neuro-oncology · 2020Trial
- Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011.Neuro-oncology · 2013Trial
- Apoptosis in alpha interferon (IFN-alpha) intratumoral chemotherapy for cystic craniopharyngiomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2007Trial
- Evaluating temozolomide for pediatric adamantinomatous craniopharyngiomas using microspheroid-based drug screening.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Craniopharyngiomas in children: the pendulum moves again for an aggressive surgery-late complications and considerations with a recent series of 26 patients treated in Lyon.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Adamantinomatous craniopharyngioma stone: is it a tumor?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Targeted Treatment of Pediatric Craniopharyngioma: Lesson Learnt After 20-Year Experience with Intracystic Interferon Alpha.Advances and technical standards in neurosurgery · 2025Article
- Integrating Systemic Therapies into the Multimodality Therapy of Patients with Craniopharyngioma.Current treatment options in oncology · 2024Review
- Feasibility, tolerability, and first experience of intracystic treatment with peginterferon alfa-2a in patients with cystic craniopharyngioma.Frontiers in oncology · 2024Article
- Adamantinomatous craniopharyngioma: evolution in the management.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Review
- Craniopharyngioma in Pediatrics and Adults.Advances in experimental medicine and biology · 2023Article
- Current Advances in the Management of Adult Craniopharyngiomas.Current oncology (Toronto, Ont.) · 2022Review
- Treatment of Cystic Craniopharyngiomas: An Update.Advances and technical standards in neurosurgery · 2022Article
- Management of pediatric craniopharyngioma: 10-year experience from high-flow center.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- The Inflammatory Milieu of Adamantinomatous Craniopharyngioma and Its Implications for Treatment.Journal of clinical medicine · 2020Review
- Canadian Pediatric Neuro-Oncology Standards of Practice.Frontiers in oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study analyzed the intratumoral activity of interferon alpha (IFN-alpha) in the treatment of cystic craniopharyngiomas. PATIENTS AND
methodsFrom January 2000 to January 2004, nine patients presenting with cystic craniopharyngiomas were treated with intratumoral injection of IFN-alpha at the Pediatric Oncology Institute of the Federal University of São Paulo-Escola Paulista de Medicina. Age ranged from 1 year and 10 months to 18 years (mean 10 years). All intratumoral catheters were inserted by a subfrontal approach. Doses varied from 36 to 108 MU.
resultsThere was complete disappearance of the lesion in seven cases. In two cases, partial reduction of tumor size was observed at follow-up. Follow-up varied from 1 year to 3 years and 6 months (mean 1 year 8 months).
conclusionsIFN-alpha proved to be an effective drug in the control of cystic craniopharyngiomas. Additional studies should be carried out to determine the optimal dose of IFN-alpha in the treatment of cystic craniopharyngioma. In addition, other drugs possessing high efficacy and low neurotoxicity should be analyzed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.