ArticlePflugers Archiv : European journal of physiology2005
Ca(2+) currents and voltage responses in Type I and Type II hair cells of the chick embryo semicircular canal.
Article in Pflugers Archiv : European journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Multi-omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells.Experimental physiology · 2026Article
- Pimozide Increases a Delayed Rectifier KBiomedicines · 2023Article
- Signal transmission in mature mammalian vestibular hair cells.Frontiers in cellular neuroscience · 2022Article
- Exocytosis in mouse vestibular Type II hair cells shows a high-order CaPhysiological reports · 2020Article
- Responses of pigeon vestibular hair cells to cholinergic agonists and antagonists.Brain research · 2011Article
- Extracellular pH modulates the voltage-dependent Ca2+ current and low threshold K+ current in hair cells.Neurochemical research · 2008Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type I and Type II hair cells, and Type II hair cells located in different zones of the semicircular canal crista, express different patterns of voltage-dependent K channels, each one specifically shaping the hair cell receptor potential. We report here that, close to hatching, chicken embryo semicircular canal Type I and Type II hair cells express a similar voltage-dependent L-type calcium current (I(Ca)), whose main features are: activation above -60 mV, fast activation kinetics, and scarce inactivation. I(Ca) should be already active at rest in Zone 1 Type II hair cells, whose resting membrane potential was on average slightly less negative than -60 mV. Conversely, I(Ca) would not be active at rest in Type II hair cells from Zone 2 and 3, nor in Type I hair cells, since their resting membrane potential was significantly more negative than -60 mV. However, even small depolarising currents would activate I(Ca) steadily in Zone 2 and 3 Type II hair cells, but not in Type I hair cells because of the robust repolarising action of their specific array of K(+) currents. The implications of the present findings in the afferent discharge are discussed.
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