ArticlePsychopharmacology2005
Habituation to test procedure modulates the involvement of dopamine D2- but not D1-receptors in ethanol-induced locomotor stimulation in mice.
Article in Psychopharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 35 citations in OpenAlex.
- The peripheral dopamine 2 receptor antagonist domperidone attenuates ethanol enhancement of dopamine levels in the nucleus accumbens.Alcoholism, clinical and experimental research · 2022Article
- Response to novelty and cocaine stimulant effects: lack of stability across environments in female Swiss mice.Psychopharmacology · 2016Article
- Different contributions of dopamine D1 and D2 receptor activity to alcohol potentiation of brain stimulation reward in C57BL/6J and DBA/2J mice.The Journal of pharmacology and experimental therapeutics · 2014Article
- Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.Behavioural brain research · 2013Article
- Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny.Frontiers in behavioral neuroscience · 2013Article
- Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2011Article
- Dopamine receptors modulate ethanol's locomotor-activating effects in preweanling rats.Developmental psychobiology · 2010Article
- Ethanol-induced hyperactivity is associated with hypodopaminergia in the 22-TNJ ENU-mutated mouse.Alcohol (Fayetteville, N.Y.) · 2009Article
- Ethanol-mediated aversive learning as a function of locomotor activity in a novel environment in infant Sprague-Dawley rats.Pharmacology, biochemistry, and behavior · 2009Article
- Novelty modulates the stimulating motor effects of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2009Article
- Combined scopolamine and ethanol treatment results in a locomotor stimulant response suggestive of synergism that is not blocked by dopamine receptor antagonists.Alcoholism, clinical and experimental research · 2009Article
- Ethanol induces locomotor activating effects in preweanling Sprague-Dawley rats.Alcohol (Fayetteville, N.Y.) · 2009Article
- Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions.The international journal of neuropsychopharmacology · 2008Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
rationaleNovelty associated with behavioral testing has been shown to enhance psychostimulant- and morphine-induced locomotor stimulation. Evidence has demonstrated that novelty increases dopamine (DA) activity, and habituation to a novel environment reduces such activation. However, it is not clear whether novelty modulates ethanol-induced behavioral stimulation and whether DA plays a role in this effect.
objectivesThe present work sought to demonstrate a role of habituation to test procedure as a factor that could modulate the involvement of DA in ethanol-induced locomotor stimulation.
methodsNon-habituated (NH) and habituated (H) Swiss mice pretreated with DA D1- (SCH23390; 0-0.045 mg/kg) or D2-receptor (sulpiride; 0-50 mg/kg) antagonists were tested for ethanol (0-2.5 g/kg)-induced locomotor stimulation. Experiments with amphetamine (0-4 mg/kg), morphine (0-5 mg/kg) and caffeine (0-15 mg/kg)were designed to compare their results to those obtained with ethanol. The effect of the non-selective opioid receptor antagonist naltrexone (0-1.5 mg/kg) was also tested on ethanol-induced locomotor stimulation.
resultsNH and H animals did not differ in their locomotor response to ethanol or caffeine; however, amphetamine- and morphine-induced stimulation was greater in NH than in H mice. SCH23390 only reduced ethanol-induced stimulation at doses that also reduced spontaneous activity in both NH and H mice. Sulpiride decreased ethanol-stimulated behavior only in the NH condition. Habituation did not modify the effect of sulpiride on amphetamine-, morphine- or caffeine-induced activation. Naltrexone (0-1.5 mg/kg) reduced ethanol-induced stimulation regardless of habituation.
conclusionsThe present data suggest that the participation of DA D2-receptors in ethanol-induced behavioral stimulation requires the presence of novelty. Results also support the involvement of neurotransmitter systems other than DA (i.e., endogenous opioid system) as important substrates mediating ethanol-induced locomotor activation.
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