ArticlePediatric nephrology (Berlin, Germany)2005
Nitric oxide modulates renal vasoconstrictor effect of endothelin-1 in conscious lambs.
Article in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs.Physiological reports · 2014Article
- Haemodynamic responses to angiotensin II in conscious lambs: role of nitric oxide and prostaglandins.Pflugers Archiv : European journal of physiology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
To test the hypothesis that nitric oxide (NO) buffers the renal vasoconstrictor effects of endothelin-1 (ET-1) early in life, renal haemodynamic responses to ET-1 were measured in the presence and absence of endogenously produced NO in conscious lambs. Renal haemodynamic effects of ET-1 were measured for 5 min before (control) and 20 min after intraarterial injection of ET-1 before and after pretreatment with 20 mg/kg of the L-arginine analogue N(G)-nitro-L-arginine methyl ester (L-NAME), (experiment 1) and its inactive isomer D-NAME (experiment 2) in conscious lambs aged approximately 1 week (N=7) and approximately 6 weeks (N=6). The two experiments were carried out in random order at intervals of 24-48 h. In lambs aged approximately 6 weeks, a marked increase in renal vascular resistance (RVR) was elicited by ET-1 administration; this response was enhanced twofold following pretreatment with L-NAME. In 1-week-old lambs, however, an increase in RVR in response to ET-1 occurred only after pretreatment with L-NAME. Therefore, we accept our hypothesis and conclude that NO buffers the renal vasoconstrictor effects of ET-1 early in life.
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