Evidence map›Paper›PMID 16133005›Full record

ReviewInternational journal of colorectal disease2007

Anal cancer in renal transplant patients.

Heena S Patel, Andrew R J Silver, John M A Northover

Abstract readReview
PubMed Publisher
In one paragraph

Review in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 110 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Delayed Diagnosis of Anal Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. High-resolution anoscopy: Unchartered territory for gastroenterologists?World journal of gastrointestinal endoscopy · 2015
    Article
  13. Article
  14. HPV-related cancers after solid organ transplantation in the United States.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013
    Article
  15. Article
  16. Article
  17. Article
  18. Anal cancer - a review.International journal of health sciences · 2012
    Article
  19. Article
  20. Human papillomavirus-related disease in men: not just a women's issue.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2010
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Heena S PatelColorectal Cancer Unit, Cancer Research UK, Level 5, St. Mark's Hospital, Harrow, Middlesex, HA1 3UJ, UK. heena2001@doctors.org.uk
Andrew R J Silver
John M A Northover
St Mark's Hospital · GBCancer Research UK · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA comprehensive literature review was performed to examine the prevalence of anal cancer, anal intraepithelial neoplasia (AIN) and anal human papillomavirus (HPV) infection in renal transplant recipients who are at risk of anal cancer due to iatrogenic immunosuppression.

methodsPertinent articles were identified from searches performed on the National Center for Biotechnology Information database using the following keywords: anal cancer, AIN, screening, renal transplant (or kidney transplant), organ transplant recipients and post-transplant malignancies.

resultsThe prevalence of AIN is 20% in renal transplant patients. The prevalence of anal HPV infection in established transplant patients is 47%, and the prevalence of anal HPV infection in new transplant patients is 23%. The relative risk for anal cancer in renal transplant patients is 10.

conclusionsAs compared to HIV-positive male patients who practise anal intercourse, renal transplant patients showed a modest rise in relative risk for anal cancer. Screening programmes to detect AIN in HIV-positive patients who practise anal intercourse have been introduced on a preliminary basis in sexual health clinics in the US and may become standard practise in this population. The case for screening in renal transplant patients is unclear and would merit further investigation, especially with reference to the prevalence of anal HPV infection in this population. It may transpire that renal transplant patients would benefit more from HPV prophylaxis rather than screening for AIN.

Indexed as

Kidney TransplantationAnus DiseasesAnus NeoplasmsCarcinoma in SituGraft RejectionHumansImmunosuppression TherapyImmunosuppressive AgentsKidney Failure, ChronicPapillomavirus InfectionsPrevalenceRisk FactorsImmunosuppressive Agents

Identifiers

PMID16133005
OpenAlexW1992403141

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.