ArticleDiabetologia2005
The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population.
Article in Diabetologia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 67 citations in OpenAlex.
- Association analysis of USF1 gene polymorphisms and total unstable carotid plaque area in atherosclerotic stroke patients.Journal of thrombosis and thrombolysis · 2013Trial
- Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity.BMC genomics · 2020Article
- Article
- The Regulation of Cbf1 by PAS Kinase Is a Pivotal Control Point for LipogenesisG3 (Bethesda, Md.) · 2019Article
- Article
- The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking.International journal of molecular sciences · 2015Article
- Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.Scientific reports · 2014Article
- Upstream stimulatory factors 1 and 2 mediate the transcription of angiotensin II binding and inhibitory protein.The Journal of biological chemistry · 2013Article
- The genetics of familial combined hyperlipidaemia.Nature reviews. Endocrinology · 2012Review
- Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice.Human molecular genetics · 2010Article
- Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- A Common Polymorphism of Upstream Transcription Factor 1 Gene is associated with Lipid Profile: A Study in Chinese Type 2 Diabetes Families.International journal of biomedical science : IJBS · 2009Article
- Glucose increases hepatic lipase expression in HepG2 liver cells through upregulation of upstream stimulatory factors 1 and 2.Diabetologia · 2008Article
- Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism.Circulation research · 2008Article
- Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases.Genome biology · 2008Article
- Psoriasis and metabolic disease: epidemiology and pathophysiology.Current opinion in rheumatology · 2008Review
- Association analysis of allelic variants of USF1 in coronary atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2008Article
- USF1 gene variants contribute to metabolic traits in men in a longitudinal 32-year follow-up study.Diabetologia · 2008Article
- Whole-genome maps of USF1 and USF2 binding and histone H3 acetylation reveal new aspects of promoter structure and candidate genes for common human disorders.Genome research · 2008Article
- Body mass index is associated with USF1 haplotype in Korean premenopausal women.Journal of Korean medical science · 2008Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
aims/hypothesisThe transcription factor upstream stimulatory factor 1 (USF1) regulates the expression of genes involved in glucose and lipid metabolism and has been associated with familial combined hyperlipidaemia. USF1 is located on chromosome 1q22-23, a region with evidence for linkage to type 2 diabetes and various traits of the metabolic syndrome in Chinese and other populations. The aim of this study was to investigate the linkage and association of USF1 with type 2 diabetes and the metabolic syndrome in Chinese individuals. MATERIALS AND
methodsWe genotyped three haplotype-tagging single nucleotide polymorphisms (SNPs) (rs3737787, rs2516841 and rs2516839) at USF1 in three samples of the Hong Kong Chinese population, including members of 179 families from the Hong Kong Family Diabetes Study, 1,383 hospital cases with type 2 diabetes and/or the metabolic syndrome and 454 normal control subjects.
resultsWe found significant association of individual polymorphisms and haplotypes with type 2 diabetes and/or metabolic syndrome-related traits in the family samples using either family-based or unrelated normal control subjects. However, these variants could not explain much of the evidence for linkage in this region. Moreover, they were not associated with type 2 diabetes and/or the metabolic syndrome in the hospital cases. CONCLUSIONS/
interpretationThe results are consistent with the hypothesis that variation at USF1 contributes to the risk of type 2 diabetes and the metabolic syndrome in families with strong evidence for linkage in the chromosome 1q region. However, they provide little support for USF1 as the susceptibility locus that generates the observed evidence for linkage at 1q21-25 for type 2 diabetes and/or the metabolic syndrome, and USF1 does not appear to have a major contribution to these phenotypes in the general Chinese population.
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