ArticleIntensive care medicine2005
A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis.
Article in Intensive care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis.mBio · 2018Article
- Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation.Microbes and infection · 2016Article
- Crystallographic analysis of Neisseria meningitidis PorB extracellular loops potentially implicated in TLR2 recognition.Journal of structural biology · 2014Article
- Cytokine and chemokine profiles in lung tissues from fatal cases of 2009 pandemic influenza A (H1N1): role of the host immune response in pathogenesis.The American journal of pathology · 2013Article
- Inflammatory cytokine measurement quickly discriminates gram-negative from gram-positive bacteremia in pediatric hematology/oncology patients with septic shock.Intensive care medicine · 2013Article
- The amino acid sequence of Neisseria lactamica PorB surface-exposed loops influences Toll-like receptor 2-dependent cell activation.Infection and immunity · 2012Article
- Treatment with TNF-alpha and IFN-gamma alters the activation of SER/THR protein kinases and the metabolic response to IGF-I in mouse c2c12 myogenic cells.Cellular & molecular biology letters · 2010Article
- Serial cytokine levels in patients with severe sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2009Article
- Article
- Elevated serum levels of IL-1ra in children with Plasmodium falciparum malaria are associated with increased severity of disease.Cytokine · 2008Article
- Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental.Intensive care medicine · 2006Review
- Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony.Molecular medicine (Cambridge, Mass.)Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveThis study aimed to determine whether an anti-inflammatory profile in meningococcal disease is associated with an increased risk of severe disease or septic shock. DESIGN AND
settingProspective observational study in a tertiary care children's hospital. PATIENTS AND
participants63 children with confirmed meningococcal disease.
interventionsPlasma concentrations of interleukin-1 receptor antagonist (IL-1Ra), interleukin-6 (IL-6), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF) were assayed on admission. Receiver operator characteristic curve analysis was used to determine optimum thresholds for IL-1Ra:TNF, IL-1Ra:IL-6 and IL-1Ra:IL-8 ratios. MEASUREMENTS AND
resultsMedian IL-1Ra:TNF and IL-1Ra:IL-6 ratios were significantly higher in severe disease with septic shock than in severe disease without septic shock and in non severe disease (IL-1Ra:TNF 263 vs. 185 vs. 108; IL-1Ra:IL-6 139 vs. 23 vs. 17). Median IL-1Ra:IL-8 ratios were not significantly different in the three groups. A significantly larger proportion of children with high IL-1Ra:TNF-alpha and IL-1Ra:IL-6 ratios developed severe disease with septic shock than those with a low ratios (95.2% vs. 4.8%; 76.2% vs. 23.8%).
conclusionsAn anti-inflammatory profile appears to be associated with the development of severe disease and septic shock in meningococcal sepsis. This may imply that experimental new therapies of pro-inflammatory cytokine inhibition and anti-inflammatory cytokines in meningococcal disease could be detrimental.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.