ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2005
The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Variant antigen repertoires inGenome research · 2018Article
- Mild Telomere Dysfunction as a Force for Altering the Adaptive Potential of Subtelomeric Genes.Genetics · 2018Article
- Transitions between the Arabidopsis-type and the human-type telomere sequence in green algae (clade Caudivolvoxa, Chlamydomonadales).Chromosoma · 2016Article
- Article
- DNA double-strand breaks and telomeres play important roles in trypanosoma brucei antigenic variation.Eukaryotic cell · 2015Review
- An alternative model for the role of RP2 protein in flagellum assembly in the African trypanosome.The Journal of biological chemistry · 2014Article
- Evidence for recycling of invariant surface transmembrane domain proteins in African trypanosomes.Eukaryotic cell · 2013Article
- Article
- Genetic structure and expression of the surface glycoprotein GP82, the main adhesin of Trypanosoma cruzi metacyclic trypomastigotes.TheScientificWorldJournal · 2013Review
- Anatomy and evolution of telomeric and subtelomeric regions in the human protozoan parasite Trypanosoma cruzi.BMC genomics · 2012Article
- Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA.Experimental parasitology · 2012Article
- Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act.Nature reviews. Microbiology · 2012Review
- Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.PLoS pathogens · 2012Article
- Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation.Molecular microbiology · 2011Article
- NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma brucei.Nucleic acids research · 2011Article
- Microhomology-mediated deletion and gene conversion in African trypanosomes.Nucleic acids research · 2011Article
- Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variation.PloS one · 2011Article
- Article
- Molecular mechanisms underlying the control of antigenic variation in African trypanosomes.Current opinion in microbiology · 2010Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Telomeres and subtelomeres are important to the virulence of a number of pathogens, as they harbour large diverse gene families associated with the maintenance of infection. Evasion of immunity by African trypanosomes involves the differential expression of variant surface glycoproteins (VSGs), which are encoded by a family of >1500 genes and pseudogenes. This silent archive is located subtelomerically and is activated by gene conversion into specialized transcription units, which themselves are subject to silencing by allelic exclusion. Current research addresses the role of telomeres in the conversion and silencing mechanisms and in the diversification of the VSG archive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.