ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2005
Making the most of a little: dosage effects in eukaryotic telomere length maintenance.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Telomerase regulation.Mutation research · 2012Review
- Telomere length is inherited with resetting of the telomere set-point.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.The Journal of biological chemistry · 2009Article
- No attenuation of the ATM-dependent DNA damage response in murine telomerase-deficient cells.DNA repair · 2009Article
- Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells.DNA repair · 2008Article
- Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance.Molecular and cellular biology · 2008Article
- Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency.RNA (New York, N.Y.) · 2006Article
- Telomere length homeostasis requires that telomerase levels are limiting.The EMBO journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomerase contains at least two essential components: the telomerase reverse transcriptase (TERT), and the telomerase RNA, which provides the template for the reverse transcription of new telomere DNA by TERT. Loss of telomerase enzymatic function leads to a progressive attrition of telomeric sequence over time, eventually resulting in the disappearance of detectable telomeric DNA and the emergence of chromosome end-to-end fusions, followed by growth arrest or cell death. Recently, the consequences of partial loss of telomerase function have revealed interesting dosage-dependent effects on telomere length and stability. In both mice and humans, hemizygosity for the telomerase RNA or TERT leads to an inability to maintain telomeres; in humans, this insufficiency can lead to diseases such as aplastic anaemia or dyskeratosis congenita. In the budding yeast S. cerevisiae, compound heterozygosity in different telomerase components also results in shortened telomeres. Thus, partial loss of telomerase function can result in a latent but measurable compromise in telomere length. These dosage-dependent effects illuminate a mechanism by which subtle heritable defects in genome integrity can eventually become pernicious.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.