ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2005
Two retrotransposons maintain telomeres in Drosophila.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 92 citations in OpenAlex.
- Lysine-36 of Drosophila histone H3.3 supports adult longevity.G3 (Bethesda, Md.) · 2024Article
- Article
- Lysine-36 ofbioRxiv : the preprint server for biology · 2023Article
- The NSL complex is required for piRNA production from telomeric clusters.Life science alliance · 2023Article
- Review
- Insights into the Role of Telomeres in Human Embryological Parameters. Opinions Regarding IVF.Journal of developmental biology · 2021Review
- Epigenetics and genome stability.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Review
- A telomerase with novel non-canonical roles: TERT controls cellular aggregation and tissue size in Dictyostelium.PLoS genetics · 2019Article
- TheThe Journal of biological chemistry · 2018Article
- Article
- SPTEdb: a database for transposable elements in salicaceous plants.Database : the journal of biological databases and curation · 2018Article
- Dissecting the Satellite DNA Landscape in Three CactophilicG3 (Bethesda, Md.) · 2017Article
- Drosophila dyskerin is required for somatic stem cell homeostasis.Scientific reports · 2017Article
- A Small RNA-Based Immune System Defends Germ Cells against Mobile Genetic Elements.Stem cells international · 2016Review
- Loss of Drosophila pseudouridine synthase triggers apoptosis-induced proliferation and promotes cell-nonautonomous EMT.Cell death & disease · 2015Article
- Insertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome Maintenance.Frontiers in genetics · 2015Review
- Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.Development (Cambridge, England) · 2014Article
- Retrotransposon long interspersed nucleotide element-1 (LINE-1) is activated during salamander limb regeneration.Development, growth & differentiation · 2012Article
- Drosophila errantiviruses.Mobile genetic elements · 2012Article
- HeT-A_pi1, a piRNA target sequence in the Drosophila telomeric retrotransposon HeT-A, is extremely conserved across copies and species.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Telomeres across the genus Drosophila are maintained, not by telomerase, but by two non-LTR retrotransposons, HeT-A and TART, that transpose specifically to chromosome ends. Successive transpositions result in long head-to-tail arrays of these elements. Thus Drosophila telomeres, like those produced by telomerase, consist of repeated sequences reverse transcribed from RNA templates. The Drosophila repeats, complete and 5'-truncated copies of HeT-A and TART, are more complex than telomerase repeats; nevertheless, these evolutionary variants have functional similarities to the more common telomeres. Like other telomeres, the Drosophila arrays are dynamic, fluctuating around an average length that can be changed by changes in the genetic background. Several proteins that interact with telomeres in other species have been found to have homologues that interact with Drosophila telomeres. Although they have hallmarks of non-LTR retrotransposons, HeT-A and TART appear to have a special relationship to Drosophila. Their Gag proteins are efficiently transported into diploid nuclei where HeT-A Gag recruits TART Gag to chromosome ends. Gags of other non-LTR elements remain predominantly in the cytoplasm. These studies provide intriguing evolutionary links between telomeres and retrotransposable elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.