ArticleMolecular and cellular biochemistry2005
Interactions between atrial natriuretic peptide and the renin-angiotensin system during salt-sensitivity exhibited by the proANP gene-disrupted mouse.
Article in Molecular and cellular biochemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension.American journal of physiology. Renal physiology · 2020Article
- Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring.Molecular and cellular biochemistry · 2015Article
- Salt feedback on the renin-angiotensin-aldosterone system.Pflugers Archiv : European journal of physiology · 2015Review
- Molecular adaptations in vasoactive systems during acute stroke in salt-induced hypertension.Molecular and cellular biochemistry · 2015Article
- Gestational hypertension and the developmental origins of cardiac hypertrophy and diastolic dysfunction.Molecular and cellular biochemistry · 2014Article
- Sex-specific differences in natriuretic peptide and nitric oxide synthase expression in ANP gene-disrupted mice.Molecular and cellular biochemistry · 2013Article
- Impaired sodium excretion and salt-sensitive hypertension in corin-deficient mice.Kidney international · 2012Article
- Altered expression of the natriuretic peptide system in genetically modified heme oxygenase-1 mice treated with high dietary salt.Molecular and cellular biochemistry · 2011Article
- Atrial natriuretic peptide increases inflammation, infarct size, and mortality after experimental coronary occlusion.American journal of physiology. Heart and circulatory physiology · 2009Article
- A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium.Circulation research · 2008Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
To understand the involvement of the systemic and cardiac components of the renin-angiotensin system (RAS) in the development of cardiac hypertrophy induced by salt intake, the present study analyzed the effect of high dietary salt (8.0% NaCl) in mice possessing a full complement (+/+) or ablation (-/-) of atrial natriuretic peptide (ANP). A 3 week treatment of 8.0% NaCl was able to induce cardiac hypertrophy in both genotypes, though exaggerated hypertrophy was noted in the ANP -/- mouse. Although a marked decrease in angiotensin II (Ang II) plasma levels in both genotypes fed a high salt diet was observed, systemic RAS mRNA components were altered only in the ANP-/- animals and remained unchanged in ANP+/+ mice. Decreased Ang II plasma levels were better correlated with decreases in angiotensinogen protein expression observed in both genotypes. High salt had no effect on cardiac RAS mRNA components in the ANP-/- animals, but did cause a significant decrease in some cardiac RAS mRNA components in ANP+/+ mice. As expected, high salt was able to increase plasma ANP levels and ventricular mRNA expression of ANP (ANP+/+ mice only) and B-type NP in both genotypes. The latter peptides are key cardiac markers of hypertrophy whose increased expression correlate well with the physical salt-induced cardiac alterations observed in this study. These findings suggest that although the RAS does not play a key role in salt-induced cardiac hypertrophy, ANP is an important determinant of the degree of salt-sensitivity observed in the proANP gene-disrupted animal.
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