ArticleClinical & experimental metastasis2005
Identification of molecular markers for metastasis-related genes in primary breast cancer cells.
Article in Clinical & experimental metastasis, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Differentially Expressed Genes in Matched Normal, Cancer, and Lymph Node Metastases Predict Clinical Outcomes in Patients With Breast Cancer.Applied immunohistochemistry & molecular morphology : AIMM · 2020Trial
- Review
- Comprehensive analysis of gene expression profiles to identify differential prognostic factors of primary and metastatic breast cancer.Saudi journal of biological sciences · 2022Article
- CD9, a tetraspanin target for cancer therapy?Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Inhibition of protein PMP22 enhances etoposide-induced cell apoptosis by p53 signaling pathway in Gastric Cancer.International journal of biological sciences · 2021Article
- Tetraspanin CD9 is Regulated by miR-518f-5p and Functions in Breast Cell Migration and In Vivo Tumor Growth.Cancers · 2020Article
- MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-κB signaling pathway in gastric cancer.International journal of biological sciences · 2020Article
- RUNX repressesScience advances · 2019Article
- Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer.British journal of cancer · 2018Article
- Transcriptome profile of the early stages of breast cancer tumoral spheroids.Scientific reports · 2016Article
- Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations.Oncotarget · 2016Article
- Review of the GAS3 Family of Proteins and their Relevance to Cancer.Critical reviews in oncogenesis · 2015Review
- TP53 mutations detected in circulating tumor cells present in the blood of metastatic triple negative breast cancer patients.Breast cancer research : BCR · 2014Article
- Role of motility-related protein-1 in promoting the development of several types of cancer (Review).Oncology letters · 2014Article
- The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression.PloS one · 2014Article
- The palmitoylation state of PMP22 modulates epithelial cell morphology and migration.ASN neuro · 2012Article
- Heterogeneity of Bcl-2 expression in metastatic breast carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2010Article
- CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinoma.BMC clinical pathology · 2009Article
- Epigenetic contributions to cancer metastasis.Clinical & experimental metastasis · 2009Article
- Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays.Breast cancer research : BCR · 2008Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Comparing differential gene expression profiles established by cDNA microarray between normal cells (N), primary carcinoma cells (T), and metastatic carcinoma cells (M) may determine those critical genes directly associated with progression and metastasis of breast cancer. Total RNA was extracted by laser microdissection (LMD) from 20 slices of T, N and M from 6 cases. After amplification by a T7-based system, differentially expressed genes between T, N and M were identified by cDNA microarray. In addition, to clarify the mechanism for altered gene expression, we determined the methylation status by sequencing after bisulfite treatment for intriguing genes. As a result, the expression of motility related protein-1 (MRP-1/CD9), peripheral myelin protein-22 (PMP-22), and caspase 3 (CASP-3) were down-regulated in M compared to T. We focused especially on MRP-1 and found that the expression status of MRP-1 was significantly inversely associated with stage of disease in 56 cases of breast cancer (P<0.05), and the relapse free survival in 5 years was significantly higher in MRP-1 positive cases than those negative cases (P<0.05). Conversely, overexpression, by 11-fold, of signal transduction and translation factors were observed in T compared to N. The cancer specific methylation was observed only in CASP-3 in a case. In conclusion, the establishment of the present assay allows us to detect genes directly associated with each cell population within tumor tissue and gives us clues to identify metastasis-related genes comprehensively in clinical breast cancer cases.
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