ReviewJournal of neuro-oncology2005
Pediatric adrenal cortical carcinoma: brain metastases and relationship to NF-1, case reports and review of the literature.
Review in Journal of neuro-oncology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Rare Association Between Neurofibromatosis Type 1 and Adrenocortical Carcinoma.Clinical case reports · 2026Article
- The molecular genetics of adrenal cushing.Hormones (Athens, Greece) · 2024Review
- Outcome of brain metastases from adrenocortical carcinoma: a pooled analysis.Journal of endocrinological investigation · 2024Article
- Disorders of the adrenal cortex: Genetic and molecular aspects.Frontiers in endocrinology · 2022Review
- Ataxia telangiectasia mutated germline pathogenic variant in adrenocortical carcinoma.Cancer genetics · 2021Article
- The Immunotherapy Landscape in Adrenocortical Cancer.Cancers · 2021Review
- What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics.Endocrine pathology · 2021Review
- Adrenocortical Carcinoma: Updates of Clinical and Pathological Features after Renewed World Health Organisation Classification and Pathology Staging.Biomedicines · 2021Review
- Adrenocortical carcinoma in a patient with neurofibromatosis type 1: A case report.Caspian journal of internal medicine · 2021Article
- Leptomeningeal Metastasis from Adrenocortical Carcinoma: A Case Report.Journal of the Endocrine Society · 2020Article
- A Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes.Journal of genetic counseling · 2017Review
- Genetics and epigenetics of adrenocortical tumors.Molecular and cellular endocrinology · 2014Review
- Adrenocortical carcinoma.Endocrine reviews · 2014Review
- Adrenal cancer in neurofibromatosis type 1: case report and DNA analysis.Endocrinology, diabetes & metabolism case reports · 2014Article
- 10 rare tumors that warrant a genetics referral.Familial cancer · 2013Review
- Association of adrenocortical carcinoma with familial cancer susceptibility syndromes.Molecular and cellular endocrinology · 2012Review
- Ectopic low-grade adrenocortical carcinoma in the spinal region: immunohistochemical and molecular cytogenetic study of a pediatric case.The American journal of surgical pathology · 2009Article
- CO-OCCURRENCE OF ADRENOCORTICAL CARCINOMA AND GASTROINTESTINAL STROMAL TUMOR IN A PATIENT WITH NEUROFIBROMATOSIS TYPE 1 AND A HISTORY OF ENDOMETRIAL CANCER.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenal cortical carcinoma (ACC) is a rare childhood neoplasm that seldom manifests brain metastases; hence few papers in the literature focus on neurological manifestations associated with ACC. Although ACC is known to be a signature tumor type in several inherited cancer predisposition syndromes, particularly Li Fraumeni, ACC has not been previously associated with neurofibromatosis, type 1 (NF-1), an inherited disorder with frequent CNS lesions that might prompt concern for metastatic disease by neuroimaging studies. We present two pediatric patients with ACC and unusual CNS findings. The first child developed metastasis to the brain 4 years after resection of his adrenal primary and 2 and 1 years, respectively, after metastases to the liver and lungs. Soon after our experience with this patient, a girl with known NF-1 presented with virilization; adrenalectomy disclosed an ACC and systemic metastases were found within months. Disseminated disease prompted concern that her complex intracranial lesions identified by neuroimaging studies might represent brain metastases, but this proved to be NF1-related hamartomatous lesions. We review the literature on ACCs in pediatric patients regarding brain metastases and previous associations with NF-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.