ArticleJournal of neuro-oncology2005
C-kit expression in germinoma: an immunohistochemistry-based study.
Article in Journal of neuro-oncology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Germinoma in late adulthood with extensive dissemination: a case report and literature review.Brain tumor pathology · 2026Article
- Intracranial Germinomas: Diagnosis, Pathogenesis, Clinical Presentation, and Management.Current oncology reports · 2023Review
- Contribution of whole slide imaging-based deep learning in the assessment of intraoperative and postoperative sections in neuropathology.Brain pathology (Zurich, Switzerland) · 2023Article
- Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors.The journal of pathology. Clinical research · 2021Article
- Intracranial Germ Cell Tumor in the Molecular Era.Journal of Korean Neurosurgical Society · 2018Review
- Pineal germ cell tumors: Two cases with review of histopathologies and biomarkers.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2017Review
- Unusual behaviour of a pineal germinoma mimicking neurosarcoidosis and metastasising along the endoscopic route.BMJ case reports · 2013Article
- Article
- Germinoma in two brothers: case report.Neurologia medico-chirurgica · 2013Review
- Primary intracranial germ cell tumors.Asian journal of neurosurgery · 2012Article
- Necrotizing infundibuloneurohypophysitis: case report and literature review.Endocrine pathology · 2012Review
- A suprasellar germ cell tumor in a 16-month-old Wagyu heifer calf.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2012Article
- HESRG: a novel biomarker for intracranial germinoma and embryonal carcinoma.Journal of neuro-oncology · 2012Article
- Expression of Zonulin, c-kit, and Glial Fibrillary Acidic Protein in Human Gliomas.Translational oncology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our immunohistochemical study of 25 human primary intracranial germinomas and germinomas with syncytiotrophoblastic giant cells (STGC), we stained the same sections for c-kit and placental alkaline phosphatase (PLAP). Immunohistochemical expression was graded using a semi-quantitative scoring system where 3+ =51-75%, and 4+ =76-100%. Of the 25 cases, 7 (28%) were graded 3+ and 18 (72%) 4+ for c-kit; 8 (32%) were 3+ or 4+ for PLAP. All 3 cases negative for PLAP-staining were strongly positive and all embryonal carcinomas, immature teratomas, and yolk sac tumors were negative for c-kit staining. The soluble isoform of c-kit (s-kit) is reportedly detectable in cerebral spinal fluid of patients with germinomas and germinomas with STGC. C-kit and s-kit may be powerful tumor markers for germinomas with or without STGC.
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