ArticlePharmaceutical research2005
Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel.
Article in Pharmaceutical research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 93 citations in OpenAlex.
- Recent development of micro-nano carriers for oral antineoplastic drug delivery.Materials today. Bio · 2025Review
- Micro- and Nanomanufacturing for Biomedical Applications and Nanomedicine: A Perspective.Small science · 2023Article
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- Nanomicelles: Types, properties and applications in drug delivery.IET nanobiotechnology · 2021Review
- Smart Polymeric Nanoparticles with pH-Responsive and PEG-Detachable Properties (II): Co-Delivery of Paclitaxel and VEGF siRNA for Synergistic Breast Cancer Therapy in Mice.International journal of nanomedicine · 2021Article
- Review
- Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma.Current neuropharmacology · 2017Review
- Perspective of Fe3O4 Nanoparticles Role in Biomedical Applications.Biochemistry research international · 2016Review
- Drug Carrier for Photodynamic Cancer Therapy.International journal of molecular sciences · 2015Review
- Comparative biophysical properties of tenofovir-loaded, thiolated and nonthiolated chitosan nanoparticles intended for HIV prevention.Nanomedicine (London, England) · 2014Article
- Effect of grafting BMP2-derived peptide to nanoparticles on osteogenic and vasculogenic expression of stromal cells.Journal of tissue engineering and regenerative medicine · 2014Article
- Eudragit-based nanosuspension of poorly water-soluble drug: formulation and in vitro-in vivo evaluation.AAPS PharmSciTech · 2012Article
- Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability.Advanced pharmaceutical bulletin · 2012Article
- pH-responsive nanoparticles releasing tenofovir intended for the prevention of HIV transmission.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2011Article
- Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery.International journal of pharmaceutics · 2011Article
- Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents.International journal of nanomedicine · 2011Review
- Novel biodegradable polylactide/poly(ethylene glycol) micelles prepared by direct dissolution method for controlled delivery of anticancer drugs.Pharmaceutical research · 2009Article
- Hydrogel matrix entrapping PLGA-paclitaxel microspheres: drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy.Pharmaceutical research · 2009Article
- Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies.Nanoscale research letters · 2008Article
- Paclitaxel loading in PLGA nanospheres affected the in vitro drug cell accumulation and antiproliferative activity.BMC cancer · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe main objective of this study was to obtain self-assembled biodegradable nanoparticles by a direct dialysis method for the delivery of anticancer drug. The in vitro cellular particle uptake and cytotoxicity to C6 glioma cell line were investigated.
methodsSelf-assembled anticancer drugs--paclitaxel-loaded poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(L-lactic acid) (PLA) nanoparticles--were achieved by direct dialysis. The physical and chemical properties of nanoparticles were characterized by various state-of-the-art techniques. The encapsulation efficiency and in vitro release profile were measured by high-performance liquid chromatography. Particle cellular uptake was studied using confocal microscopy, microplate reader, and flow cytometry. In addition, the cytotoxicity of this drug delivery system was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay on C6 glioma cell line to predict the possible dose response of paclitaxel-loaded PLGA and PLA nanoparticles.
resultsPLGA and PLA nanoparticles with or without vitamin E tocopherol polyethylene glycol succinate (TPGS) as an additive were obtained, in which the sustained release of paclitaxel of more than 20 days was achieved. The coumarin6-loaded PLGA and PLA nanoparticles could penetrate the C6 glioma cell membrane and be internalized. The cytotoxicity of paclitaxel-loaded nanoparticles seemed to be higher than that of commercial Taxol after 3 days incubation when paclitaxel concentrations were 10 and 20 microg/ml.
conclusionsDirect dialysis could be employed to achieve paclitaxel-loaded PLGA and PLA nanoparticles, which could be internalized by C6 glioma cells and enhance the cytotoxicity of paclitaxel because of its penetration to the cytoplasm and sustained release property.
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