ArticlePediatric cardiology
Angiogenesis in fatal acute Kawasaki disease coronary artery and myocardium.
Article in Pediatric cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Autoptic Findings in Cases of Sudden Death Due to Kawasaki Disease.Diagnostics (Basel, Switzerland) · 2023Article
- Case Report: Structural Changes in the Coronary Vessel Wall in a Patient With Incomplete Kawasaki Disease.Frontiers in pediatrics · 2022Article
- IL-1-dependent electrophysiological changes and cardiac neural remodeling in a mouse model of Kawasaki disease vasculitis.Clinical and experimental immunology · 2020Article
- Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance.Human immunology · 2010Article
- Pathogenesis and management of Kawasaki disease.Expert review of anti-infective therapy · 2010Review
- Epidemiologic features of Kawasaki disease in Japan: results of the 2007-2008 nationwide survey.Journal of epidemiology · 2010Article
- Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease.Journal of clinical laboratory analysis · 2009Article
- Searching for the cause of Kawasaki disease--cytoplasmic inclusion bodies provide new insight.Nature reviews. Microbiology · 2008Review
- Epidemiologic features of Kawasaki disease in Japan: results from the nationwide survey in 2005-2006.Journal of epidemiology · 2008Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Angiogenesis has been shown to be dysregulated in coronary artery (CA) aneurysms in the chronic phase of Kawasaki disease (KD). Neovascularization may occur in inflammatory-related vascular diseases because many angiogenesis mediators are secreted by inflammatory cells. We hypothesized that inflammation of the acute KD CA aneurysm could lead to dysregulation of angiogenesis mediators and subsequent neovascularization. To investigate this hypothesis, acute fatal KD cardiac tissues were immunostained for angiogenic inducers and inhibitors. Microvessel density was determined and the degree of inflammation assessed. Marked inflammation and angiogenesis were found in acute KD CA aneurysms and myocardium, with the highest microvessel density seen in patients who died 2-3 weeks after onset of the disease. Expression of proangiogenic proteins was higher than expression of inhibitors in KD CA aneurysms and myocardium. Angiogenesis mediators were localized to inflammatory cells in the myointima, adventitia, and myocardium. We conclude that significant neovascularization occurs in acute KD CA aneurysms and myocardium much sooner after onset of the disease than has been previously reported, that multiple angiogenesis factors are involved, and that dysregulation of angiogenesis likely contributes to KD vasculopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.