ReviewPituitary2004
The Nelson's syndrome... revisited.
Review in Pituitary, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis.Pituitary · 2021Pooled it
- Recurrence after pituitary surgery in adult Cushing's disease: a systematic review on diagnosis and treatment.Endocrine · 2020Pooled it
- ACTH increment post total bilateral adrenalectomy for Cushing's disease: a consistent biosignature for predicting Nelson's syndrome.Pituitary · 2020Article
- Long-term outcome after bilateral adrenalectomy in Cushing's disease with focus on Nelson's syndrome.Archives of endocrinology and metabolism · 2019Article
- Article
- Recent advances in understanding corticotroph pituitary tumor initiation and progression.F1000Research · 2018Review
- The Treatment of Cushing's Disease.Endocrine reviews · 2015Review
- Positron emission tomography-computed tomography coregistration for diagnosis and intraoperative localization in recurrent nelson syndrome.Journal of neurological surgery reports · 2013Article
- Management Strategies for Aggressive Cushing's Syndrome: From Macroadenomas to Ectopics.Journal of oncology · 2012Article
- Cushing's Disease: Pituitary Surgery versus Adrenalectomy.Sultan Qaboos University medical journal · 2008Article
- Treatment of adrenocorticotropin-dependent Cushing's syndrome: a consensus statement.The Journal of clinical endocrinology and metabolism · 2008Review
- Surgery for Cushing's syndrome: an historical review and recent ten-year experience.World journal of surgery · 2008Review
- Improved quality of life after bilateral laparoscopic adrenalectomy for Cushing's disease: a 10-year experience.Annals of surgery · 2007Article
- Bilateral adrenalectomy for Cushing's syndrome: Pros and cons.Indian journal of endocrinology and metabolismArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adrenalectomy is a radical therapeutic approach to control hypercortisolism in some patients with Cushing's disease. However it may be complicated by the Nelson's syndrome, defined by the association of a pituitary macroadenoma and high ACTH secretion after adrenalectomy. This definition has not changed since the end of the fifties. Today the Nelson's syndrome must be revisited with new to criteria using more sensitive diagnostic tools, especially the pituitary magnetic resonance imaging. In this paper we will review the pathophysiological aspects of corticotroph tumor growth, with reference to the impact of adrenalectomy. The main epidemiological data on the Nelson's syndrome will be presented. More importantly, we will propose a new pathophysiological and practical approach to this question which attempts to evaluate the Corticotroph Tumor Progression after adrenalectomy, rather than to diagnose the Nelson's syndrome. We will discuss the consequences for the management of Cushing's disease patients after adrenalectomy, and will also draw some perspectives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.