ArticlePLoS genetics2005
Comparative genomics of natural killer cell receptor gene clusters.
Article in PLoS genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
113 citing papers in PubMed, 291 citations in OpenAlex.
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- An evolutionary genomic perspective on preterm birth, genome editing, and pregnancy in the human species.Frontiers in genome editing · 2026Review
- Exceptional diversity of allorecognition receptors in a nonvertebrate chordate reveals principles of innate allelic discrimination.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Histocompatibility in Botryllus schlosseri and the origins of adaptive immunity.Immunogenetics · 2025Review
- Profiling genetically driven alternative splicing across the Indonesian archipelago.American journal of human genetics · 2024Article
- Genetic and functional diversity of allorecognition receptors in the urochordate,bioRxiv : the preprint server for biology · 2024Article
- Immune receptors and aging brain.Bioscience reports · 2024Review
- Comparative genomics of the Natural Killer Complex in carnivores.Frontiers in immunology · 2024Article
- Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells.Science immunology · 2023Article
- Comparative Characterization of Immune Response in Sheep with Caseous Lymphadenitis through Analysis of the Whole Blood Transcriptome.Animals : an open access journal from MDPI · 2023Article
- Article
- Comparative genomics of the Leukocyte Receptor Complex in carnivores.Frontiers in immunology · 2023Article
- Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV.Frontiers in immunology · 2023Article
- Carcinogenesis resistance in the longest-lived rodent, the naked mole-rat.Cancer science · 2022Review
- Best genome sequencing strategies for annotation of complex immune gene families in wildlife.GigaScience · 2022Article
- A family of unusual immunoglobulin superfamily genes in an invertebrate histocompatibility complex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanisms for Host Immune Evasion Mediated byFrontiers in immunology · 2022Review
- Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.Frontiers in genetics · 2022Review
- Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Many receptors on natural killer (NK) cells recognize major histocompatibility complex class I molecules in order to monitor unhealthy tissues, such as cells infected with viruses, and some tumors. Genes encoding families of NK receptors and related sequences are organized into two main clusters in humans: the natural killer complex on Chromosome 12p13.1, which encodes C-type lectin molecules, and the leukocyte receptor complex on Chromosome 19q13.4, which encodes immunoglobulin superfamily molecules. The composition of these gene clusters differs markedly between closely related species, providing evidence for rapid, lineage-specific expansions or contractions of sets of loci. The choice of NK receptor genes is polarized in the two species most studied, mouse and human. In mouse, the C-type lectin-related Ly49 gene family predominates. Conversely, the single Ly49 sequence is a pseudogene in humans, and the immunoglobulin superfamily KIR gene family is extensive. These different gene sets encode proteins that are comparable in function and genetic diversity, even though they have undergone species-specific expansions. Understanding the biological significance of this curious situation may be aided by studying which NK receptor genes are used in other vertebrates, especially in relation to species-specific differences in genes for major histocompatibility complex class I molecules.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.