ArticleProceedings of the National Academy of Sciences of the United States of America2005
Regulation of synaptic plasticity in a schizophrenia model.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Insulin-like Growth Factor Family as a Potential Peripheral Biomarker in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis.Journal of autism and developmental disorders · 2022Pooled it
- Network-based drug repurposing for schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Hippocampal area CA2: interneuron disfunction during pathological states.Frontiers in neural circuits · 2023Review
- Neuronal Plasticity: Neuronal Organization is Associated with Neurological Disorders.Journal of molecular neuroscience : MN · 2020Review
- Epigenetic Regulation of Glutamic Acid Decarboxylase 67 in a Hippocampal Circuit.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Characterization of a Novel Mutation in SLC1A1 Associated with Schizophrenia.Molecular neuropsychiatry · 2015Article
- Conscious experience and episodic memory: hippocampus at the crossroads.Frontiers in psychology · 2013Article
- Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia.PloS one · 2012Article
- Amygdalocortical circuitry in schizophrenia: from circuits to molecules.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Review
- Functional magnetic resonance imaging (fMRI) of attention processes in presumed obligate carriers of schizophrenia: preliminary findings.Annals of general psychiatry · 2008Article
- The evolution of drug development in schizophrenia: past issues and future opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008Review
- Prolonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex.Journal of neurophysiology · 2008Article
- Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia.Trends in neurosciences · 2008Review
- Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.Molecular psychiatry · 2007Article
- The anatomy of co-morbid neuropsychiatric disorders based on cortico-limbic synaptic interactions.Neurotoxicity research · 2006Review
- Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Glutamate and schizophrenia: beyond the dopamine hypothesis.Cellular and molecular neurobiologyReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The pathology of schizophrenia is characterized by increased hippocampal activity at baseline and during auditory hallucinations. Animal-model studies in which the flow of activity to the hippocampus is increased through decreased amygdalar GABAergic inhibition have shown alterations of hippocampal circuitry similar to schizophrenia, but the functional importance of this phenomenon remains unclear. We provide evidence of decreased hippocampal feed-forward and tonic GABA-mediated inhibition in this animal model, complementing increased hippocampal activity seen in neuroimaging and postmortem studies. We demonstrate that GABA dysfunction increases long-term potentiation through activation of the cholinergic system, offering a new mechanism for pharmacological strategies of this disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.