ReviewCurrent neurology and neuroscience reports2005
Genetics of cerebral cavernous malformations.
Review in Current neurology and neuroscience reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 72 citations in OpenAlex.
- KRIT1 in vascular biology and beyond.Bioscience reports · 2024Review
- Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels.APL bioengineering · 2024Article
- Hemorrhagic stroke in children.Journal of central nervous system disease · 2024Review
- Article
- Review
- Signalling through cerebral cavernous malformation protein networks.Open biology · 2020Review
- Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.The Journal of experimental medicine · 2020Article
- Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.PLoS biology · 2020Article
- High Prevalence of Spinal Cord Cavernous Malformations in the Familial Cerebral Cavernous Malformations Type 1 Cohort.AJNR. American journal of neuroradiology · 2020Article
- Comparative omics of CCM signaling complex (CSC).Chinese neurosurgical journal · 2020Article
- Article
- Article
- Dysregulated exocytosis of angiopoietin-2 drives cerebral cavernous malformation.Nature medicine · 2016Article
- Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.Nature · 2016Article
- Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Rho kinase as a target for cerebral vascular disorders.Future medicinal chemistry · 2015Review
- Lack of CCM1 induces hypersprouting and impairs response to flow.Human molecular genetics · 2014Article
- Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.Cellular and molecular life sciences : CMLS · 2014Review
- The association between cerebral developmental venous anomaly and concomitant cavernous malformation: an observational study using magnetic resonance imaging.BMC neurology · 2014Observational
- Neurovascular development and links to disease.Cellular and molecular life sciences : CMLS · 2013Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past few years have seen rapid advances in our understanding of the genetics and molecular biology of cerebral cavernous malformations (CCM). This article summarizes the recent cloning of the CCM1, CCM2, and CCM3 genes, which are responsible for autosomal dominant CCM, and also describes current hypotheses for their roles in integrin and p38 mitogen-activated protein kinase- mediated regulation of angiogenesis. A mouse model of CCM has been generated by mutation of the Ccm1 gene, and it indicates a role for that protein in arterial development. Future studies will probably focus on integration of data from each of the three CCM genes into a single model of the pathogenesis of cavernous malformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.