ArticleAnnals of neurology2005
Phosphodiesterase 4D and 5-lipoxygenase activating protein in ischemic stroke.
Article in Annals of neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 9 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Clinical implications of fracture severity risk with pioglitazone: a systematic review and meta-analysis of clinical randomized trials.Frontiers in pharmacology · 2025Pooled it
- Phosphodiesterase 4 D (PDE4D) gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis.Acta neurologica Belgica · 2023Pooled it
- Pooled it
- Association between PDE4D rs966221 polymorphism and risk of ischemic stroke: a systematic review and meta-analysis.Metabolic brain disease · 2018Pooled it
- The SG13S114 polymorphism of the ALOX5AP gene is associated with ischemic stroke in Europeans: a meta-analysis of 8062 subjects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Pooled it
- A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene.European journal of human genetics : EJHG · 2012Pooled it
- Meta-analysis of association between variation in the PDE4D gene and ischemic cerebral infarction risk in Asian populations.Neurogenetics · 2010Pooled it
- Multilocus Bayesian meta-analysis of gene-disease associations.American journal of human genetics · 2009Pooled it
- Association between phosphodiesterase 4D gene and ischaemic stroke.Journal of neurology, neurosurgery, and psychiatry · 2006Pooled it
- Lack of association betweenNeuropsychiatric disease and treatment · 2019Article
- No Association Between Single-Nucleotide Polymorphism 56 (SNP56) in Phosphodiesterase 4D (PDE4D) Gene and Susceptibility to Ischemic Stroke: A Meta-Analysis of 15 Studies.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Genetic polymorphisms of T-1131C APOA5 and ALOX5AP SG13S114 with the susceptibility of ischaemic stroke in Morocco.Journal of genetics · 2016Article
- Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project.JAMA neurology · 2015Article
- Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
- PDE4D gene polymorphisms and coronary heart disease: a case-control study in a north Indian population.Journal of clinical laboratory analysis · 2013Article
- Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study.Atherosclerosis · 2013Article
- Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China.BMC medical genetics · 2012Article
- Association of ALOX5AP with ischemic stroke in eastern Chinese.World journal of emergency medicine · 2012Article
- A tagging SNP in ALOX5AP and risk of stroke: a haplotype-based analysis among eastern Chinese Han population.Molecular biology reports · 2011Article
- Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of ischemic stroke in Han Chinese of eastern China.Journal of biomedical research · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 1 country.
Funding
Abstract
Risk for ischemic stroke is mediated by both environmental and genetic factors. Although several environmental exposures have been implicated, relatively little is known about the genetic basis of predisposition to this disease. Recent studies in Iceland identified risk polymorphisms in two putative candidate genes for ischemic stroke: phosphodiesterase 4D (PDE4D) and 5-lipoxygenase activating protein (ALOX5AP). A collection of North American sibling pairs concordant for ischemic stroke and two cohorts of prospectively ascertained North American ischemic stroke cases and control subjects were used for evaluation of PDE4D and ALOX5AP. Although no evidence supported linkage of ischemic stroke with either of the two candidate genes, single-nucleotide polymorphisms and haplotypic associations were observed between PDE4D and ischemic stroke. There was no evidence of association between variants of ALOX5AP and ischemic stroke. These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.