Evidence map›Paper›PMID 16130014›Full record

ArticleProstate cancer and prostatic diseases2005

Genome-wide screening for genetic changes in a matched pair of benign and prostate cancer cell lines using array CGH.

N Brookman-Amissah, C Duchesnes, M P Williamson, Q Wang, A Ahmed, M R Feneley, A Mackay, A Freeman, K Fenwick, M Iravani and 3 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Prostate cancer and prostatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Clinical Correlates of Autosomal Chromosomal Abnormalities in an Electronic Medical Record-Linked Genome-Wide Association Study: A Case Series.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2013
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

N Brookman-AmissahProstate Cancer Research Centre, Institute of Urology, University College London, London, UK.
C Duchesnes
M P Williamson
Q Wang
A Ahmed
M R Feneley
A Mackay
A Freeman
K Fenwick
M Iravani
B Weber
A Ashworth
J R Masters
Prostate Cancer Research · GBInstitute of Cancer Research · GBUniversity College London · GBBreast Cancer Now · GBUniversity of Pennsylvania · US

Funding

Breast Cancer Now BREAST CANCER NOW RESEARCH CENTREMedical Research Council G0100116
6 · The paper itself

Abstract

Copy number alterations in a matched pair of benign epithelial and prostate cancer cell lines derived from the same patient were assessed using array-based comparative genomic hybridisation (aCGH). The cancer cell line showed a gain of chromosome 7, deletion of chromosome 8, gains (including high level) and losses on chromosome 11, loss of 18p and gain of 20q. Deletions on chromosome 8 were confirmed with microsatellite markers. The aCGH results were compared to gene expression data obtained using DNA microarrays and suggested the involvement of caspases and ICEBERG on 11q and E2F1 on chromosome 20q.

Indexed as

Genome, HumanCell Line, TumorChromosomes, HumanGene Expression Regulation, NeoplasticGenetic TestingHeterozygoteHumansLoss of HeterozygosityMaleMicroarray AnalysisMicrosatellite RepeatsNucleic Acid HybridizationProstateProstatic Neoplasms

Identifiers

PMID16130014
OpenAlexW2146504178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.