ReviewClinical reviews in allergy & immunology2005
Negative regulation of cytokine signaling.
Review in Clinical reviews in allergy & immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress viaMaterials today. Bio · 2025Article
- Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production.Animals : an open access journal from MDPI · 2020Review
- Curcumin abrogates LPS-induced pro-inflammatory cytokines in RAW 264.7 macrophages. Evidence for novel mechanisms involving SOCS-1, -3 and p38 MAPK.Archives of oral biology · 2013Article
- Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- SOCS proteins in infectious diseases of mammals.Veterinary immunology and immunopathology · 2013Review
- Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells.Biochemical and biophysical research communications · 2012Article
- Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism.PloS one · 2012Article
- Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus.Nature immunology · 2011Article
- Role of cytokines as mediators and regulators of microglial activity in inflammatory demyelination of the CNS.Neuromolecular medicine · 2010Review
- Expression of signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 in urothelial carcinoma.The Kaohsiung journal of medical sciences · 2009Article
- IFN{gamma} regulates retinal pigment epithelial fluid transport.American journal of physiology. Cell physiology · 2009Article
- Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells.Journal of cancer research and clinical oncology · 2009Article
- Dynamics of receptor and protein transducer homodimerisation.BMC systems biology · 2008Article
- Article
- Mechanisms of over-activated innate immune system regulation in autoimmune and neurodegenerative disorders.Neuropsychiatric disease and treatment · 2007Article
- The role of STATs in lung carcinogenesis: an emerging target for novel therapeutics.Journal of molecular medicine (Berlin, Germany) · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.
Indexed as
Identifiers
16129905What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.