ArticleThe Journal of experimental medicine2005
IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 96 citations in OpenAlex.
- Article
- Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases.Biomedicines · 2022Review
- Microscopic and molecular evaluation of Strongyloides venezuelensis in an experimental life cycle using Wistar rats.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents.Parasites & vectors · 2020Article
- Interleukin-18 in Health and Disease.International journal of molecular sciences · 2019Review
- Sequential Changes in the Host Gut Microbiota During Infection With the Intestinal Parasitic NematodeFrontiers in cellular and infection microbiology · 2019Article
- The contribution of mast cells to bacterial and fungal infection immunity.Immunological reviews · 2018Review
- Interleukin-18 has an Important Role in Differentiation and Maturation of Mucosal Mast Cells.Journal of mucosal immunology research · 2018Article
- Nematode-Infected Mice Acquire Resistance to Subsequent Infection With Unrelated Nematode by Inducing Highly Responsive Group 2 Innate Lymphoid Cells in the Lung.Frontiers in immunology · 2018Article
- Unique Action of Interleukin-18 on T Cells and Other Immune Cells.Frontiers in immunology · 2018Review
- Differences in the Importance of Mast Cells, Basophils, IgE, and IgG versus That of CD4Infection and immunity · 2017Article
- Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System.Frontiers in immunology · 2017Review
- The Immunology of Wild Rodents: Current Status and Future Prospects.Frontiers in immunology · 2017Review
- IgE and mast cells in host defense against parasites and venoms.Seminars in immunopathology · 2016Review
- Roles and relevance of mast cells in infection and vaccination.Journal of biomedical research · 2016Review
- Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18.Mediators of inflammation · 2016Article
- Effect of different stages of Schistosoma mansoni infection on the parasite burden and immune response to Strongyloides venezuelensis in co-infected mice.Parasitology research · 2015Article
- Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.European journal of immunology · 2015Article
- Potential effector and immunoregulatory functions of mast cells in mucosal immunity.Mucosal immunology · 2015Review
- Interleukin-1 Family Cytokines in Liver Diseases.Mediators of inflammation · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C57BL/6 (B6) and B6 background STAT6(-/-) mice pretreated with IL-18 plus IL-2 showed prominent intestinal mastocytosis and rapidly expelled implanted adult worms of the gastrointestinal nematode Strongyloides venezuelensis. In contrast, identically pretreated mast cell-deficient W/W(v) mice failed to do so. Thus, activated mucosal mast cells (MMC) are crucial for parasite expulsion. B6 mice infected with S. venezuelensis third-stage larvae (L3) completed parasite expulsion by day 12 after infection, whereas IL-18(-/-) or IL-18Ralpha(-/-) B6 mice exhibited marked impairment in parasite expulsion, suggesting a substantial contribution of IL-18-dependent MMC activation to parasite expulsion. Compared with IL-18(-/-) or IL-18Ralpha(-/-) mice, S. venezuelensis L3-infected STAT6(-/-) mice have poorly activated MMC and sustained infection; although their IL-18 production is normal. Neutralization of IL-18 and IL-2 further reduces expulsion in infected STAT6(-/-) mice. These results suggest that collaboration between IL-18-dependent and Th2 cell-dependent mastocytosis is important for prompt parasite expulsion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.