ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2005
Expression of nestin-green fluorescent protein transgene marks oval cells in the adult liver.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 65 citations in OpenAlex.
- Detection of De Novo Dividing Stem Cells In Situ through Double Nucleotide Analogue Labeling.Cells · 2022Article
- Nestin Expression Is Associated with Relapses in Head and Neck Lesions.Diagnostics (Basel, Switzerland) · 2021Article
- Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression.Advances in cancer research · 2021Review
- Transgenic models for investigating the nervous system: Currently available neurofluorescent reporters and potential neuronal markers.Biochimica et biophysica acta. General subjects · 2020Review
- Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.Cancer cell · 2019Article
- Hepatic stellate cells derived from the nestin-positive cells in septum transversum during rat liver development.Medical molecular morphology · 2018Article
- Article
- Viral and transgenic reporters and genetic analysis of adult neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Turning hepatic cancer stem cells inside out--a deeper understanding through multiple perspectives.Molecules and cells · 2015Review
- Tensile forces applied on a cell-embedded three-dimensional scaffold can direct early differentiation of embryonic stem cells toward the mesoderm germ layer.Tissue engineering. Part A · 2015Article
- Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes.Cell stem cell · 2014Article
- Brain stem cell division and maintenance studied using multi-isotope imaging mass spectrometry (MIMS).Surface and interface analysis : SIA · 2014Article
- p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.Cell · 2014Article
- The diagnostic importance of matrix metalloproteinase-7 and nestin in gastrointestinal stromal tumors.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain.The European journal of neuroscience · 2013Article
- Contributions of new hepatocyte lineages to liver growth, maintenance, and regeneration in mice.Hepatology (Baltimore, Md.) · 2011Article
- Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Article
- Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Inducible site-specific recombination in neural stem/progenitor cells.Genesis (New York, N.Y. : 2000) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Oval cells, which become apparent in the liver after chronic injury, serve as bipotent progenitors for differentiated hepatocytes and cholangiocytes. We found that, in the liver of adult transgenic mice in which expression of green fluorescent protein (GFP) is driven by regulatory elements of the nestin gene, the GFP signal marks a subpopulation of small epithelial cells that meet the criteria for oval cells, including morphology, localization, antigenic profile, and reactivity in response to injury. In the regenerating and developing liver, we also found nestin-GFP-positive cells that express hepatocyte markers; such cells may correspond to transiently appearing differentiating progeny of oval cells. During development, GFP-expressing cells in the liver emerge relatively late, after the appearance of differentiated hepatocytes and cholangiocytes. Our results suggest that nestin-GFP cells in the liver correspond to a specialized cell type whose primary function may be to serve as a reserve for adult liver epithelial cell types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.