ArticleThe American journal of pathology2005
The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of helicobacter-induced mucosa-associated lymphoid tissue lymphoma.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2022Pooled it
- Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma.PloS one · 2016Trial
- Helicobacter pylori-negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis.American journal of clinical pathology · 2023Article
- Anti-CD40L therapy prevents the formation of precursor lesions to gastric B-cell MALT lymphoma in a mouse model.The Journal of pathology · 2023Article
- Antibiotic and glucocorticoid-induced recapitulated hematological remission in acute myeloid leukemia: A case report and review of literature.World journal of clinical cases · 2022Article
- Novel Insights of Lymphomagenesis ofCancers · 2019Review
- Relationship of the mucosal microbiota to gastrointestinal inflammation and small cell intestinal lymphoma in cats.Journal of veterinary internal medicine · 2018Article
- Reproducibility of histopathological findings in experimental pathology of the mouse: a sorry tail.Lab animal · 2017Article
- Interferon-γ promotes gastric lymphoid follicle formation but not gastritis inGut pathogens · 2016Article
- Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth.Mucosal immunology · 2015Article
- Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection.Mucosal immunology · 2015Article
- Helicobacter pylori: Genomic Insight into the Host-Pathogen Interaction.International journal of genomics · 2015Review
- B-cell receptor signaling as a driver of lymphoma development and evolution.Seminars in cancer biology · 2013Review
- Detection of the Helicobacter pylori CagA protein in gastric mucosa-associated lymphoid tissue lymphoma cells: clinical and biological significance.Blood cancer journal · 2013Article
- Is elevated gastric tissue NOX2 associated with lymphoma of mucosa-associated lymphoid tissue?Antioxidants & redox signaling · 2012Article
- The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammation.Journal of molecular medicine (Berlin, Germany) · 2010Article
- B-cell receptor signaling and CD40 ligand-independent T cell help cooperate in Helicobacter-induced MALT lymphomagenesis.Leukemia · 2010Article
- Bcl-2 expression is altered with ovarian tumor progression: an immunohistochemical evaluation.Journal of ovarian research · 2009Article
- Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas.Haematologica · 2009Review
- Gastric Helicobacter species as a cause of feline gastric lymphoma: a viable hypothesis.Veterinary immunology and immunopathology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Gastric B-cell lymphoma of mucosa-associated lymphoid tissue type is closely linked to chronic Helicobacter pylori infection. Most clinical and histopathological features of the tumor can be reproduced by prolonged Helicobacter infection of BALB/c mice. In this study, we have addressed the role of antigenic stimulation in the pathogenesis of the lymphoma by experimental infection with Helicobacter felis, followed by antibiotic eradication therapy and subsequent re-infection. Antimicrobial therapy was successful in 75% of mice and led to complete histological but not "molecular" tumor remission. Although lympho-epithelial lesions disappeared and most gastric lymphoid aggregates resolved, transcriptional profiling revealed the long-term mucosal persistence of residual B cells. Experimental re-introduction of Helicobacter led to very rapid recurrence of the lymphomas, which differed from the original lesions by higher proliferative indices and more aggressive behavior. Immunophenotyping of tumor cells revealed massive infiltration of lesions by CD4(+) T cells, which express CD 28, CD 69, and interleukin-4 but not interferon-gamma, suggesting that tumor B-cell proliferation was driven by Th 2-polarized, immunocompetent, and activated T cells. Tumors were also densely colonized by follicular dendritic cells, whose numbers were closely associated with and predictive of treatment outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.