ArticleAntimicrobial agents and chemotherapy2005
Interleukin-8-derived peptide has antibacterial activity.
Article in Antimicrobial agents and chemotherapy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Identification, Expression and Antimicrobial Functional Analysis of Interleukin-8 (IL-8) in Response toAnimals : an open access journal from MDPI · 2024Article
- The Double-Edged Sword of Beta2-Microglobulin in Antibacterial Properties and Amyloid Fibril-Mediated Cytotoxicity.International journal of molecular sciences · 2021Review
- Investigating Both Mucosal Immunity and Microbiota in Response to Gut Enteritis in Yellowtail Kingfish.Microorganisms · 2020Article
- Biliary Tract Carcinogenesis Model Based on Bile Metaproteomics.Frontiers in oncology · 2020Article
- IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Article
- Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity.PloS one · 2019Article
- What Can Pleiotropic Proteins in Innate Immunity Teach Us about Bioconjugation and Molecular Design?Bioconjugate chemistry · 2018Review
- PIP-EL: A New Ensemble Learning Method for Improved Proinflammatory Peptide Predictions.Frontiers in immunology · 2018Article
- Saliva-Derived Host Defense Peptides Histatin1 and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1Journal of immunology research · 2017Article
- pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents.Pharmaceuticals (Basel, Switzerland) · 2016Review
- Chemokine-Derived Peptides: Novel Antimicrobial and Antineoplasic Agents.International journal of molecular sciences · 2015Review
- CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Structural perspectives on antimicrobial chemokines.Frontiers in immunology · 2012Article
- Antimicrobial activities of chemokines: not just a side-effect?Frontiers in immunology · 2012Article
- Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements.The Journal of biological chemistry · 2011Article
- Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers.Biochemistry · 2009Article
- Human macrophage inflammatory protein 3alpha: protein and peptide nuclear magnetic resonance solution structures, dimerization, dynamics, and anti-infective properties.Antimicrobial agents and chemotherapy · 2008Article
- Modular determinants of antimicrobial activity in platelet factor-4 family kinocidins.Biochimica et biophysica acta · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemokines are inflammatory mediators with effects on diverse processes associated with the immune response. Some of the proteins belonging to the CXC chemokine subfamily, one of four groups in the family, possess inherent antibacterial activity against a wide range of bacteria. The CXC chemokine interleukin-8 (IL-8) has not been ascribed any direct antibacterial activity, but the fact that several of the amino acids in the carboxy-terminal part of the protein are identical or similar to those in a bactericidal cecropin-like peptide [Hp(2-20)] from Helicobacter pylori suggests that processing of the cytokine might generate peptide fragments with antibacterial properties. Synthetic peptides representing the carboxy-terminal part of IL-8 were investigated for antibacterial activities. These fragments possessed an antibacterial activity absent in the full-length IL-8. The antibacterial effects were reduced at increasing salt concentrations whereas the activity was increased when the pH was lowered. The IL-8-derived peptide shared structural similarity with and was also functionally additive to the Hp(2-20) peptide. The IL-8-derived peptide lacked the proinflammatory effects of the full-length protein. We also showed that acid hydrolysis of IL-8 generated a major peptide fragment corresponding to the antibacterial carboxyl terminus of the protein. The results presented are of special interest when put in the context of the suggested importance of antimicrobial peptides for microbial colonization of the gastric mucosa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.