ArticleJournal of clinical pathology2005
Interstitial cells of Cajal, enteric nerves, and glial cells in colonic diverticular disease.
Article in Journal of clinical pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 153 citations in OpenAlex.
- Global research status and trends of enteric glia: a bibliometric analysis.Frontiers in pharmacology · 2024Pooled it
- Epidemiology and risk factors for diverticular disease.Acta bio-medica : Atenei Parmensis · 2018Pooled it
- Structural Alterations in Diverticular Disease.Clinics in colon and rectal surgery · 2025Review
- Bowel movement alterations predict the severity of diverticular disease and the risk of acute diverticulitis: a prospective, international study.Intestinal research · 2025Article
- Recent updates on classification and unsolved issues of diverticular disease: a narrative review.Journal of Yeungnam medical science · 2024Article
- CaPhysiological reviews · 2024Review
- Prior abdominal surgery as a potential risk factor for colonic diverticulosis or diverticulitis.World journal of clinical cases · 2023Article
- Diverticulosis and Diverticulitis: Epidemiology, Pathophysiology, and Current Treatment Trends.Cureus · 2023Review
- 150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility.Cell genomics · 2023Article
- Diverticulitis is a population health problem: Lessons and gaps in strategies to implement and improve contemporary care.World journal of gastrointestinal surgery · 2023Review
- "M1/M2" Muscularis Macrophages Are Associated with Reduction of Interstitial Cells of Cajal and Glial Cells in Achalasia.Digestive diseases and sciences · 2023Article
- Article
- Symptomatic Uncomplicated Diverticular Disease (SUDD): Practical Guidance and Challenges for Clinical Management.Clinical and experimental gastroenterology · 2023Review
- Pathophysiology of Diverticular Disease: From Diverticula Formation to Symptom Generation.International journal of molecular sciences · 2022Review
- Evaluation of molecular and genetic predisposing parameters at diverticular disease of the colon.International journal of colorectal disease · 2021Review
- Update on the management of sigmoid diverticulitis.World journal of gastroenterology · 2021Review
- High-Resolution Colonic Manometry Pressure Profiles Are Similar in Asymptomatic Diverticulosis and Controls.Digestive diseases and sciences · 2021Article
- Understanding the Natural History of the Disease.Seminars in colon & rectal surgery · 2021Article
- Robust, 3-Dimensional Visualization of Human Colon Enteric Nervous System Without Tissue Sectioning.Gastroenterology · 2020Article
- Colonic diverticular disease.Nature reviews. Disease primers · 2020Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColonic diverticular disease (diverticulosis) is a common disorder in Western countries. Although its pathogenesis is probably multifactorial, motor abnormalities of the large bowel are thought to play an important role. However, little is known about the basic mechanism that may underlie abnormal colon motility in diverticulosis.
aimsTo investigate the interstitial cells of Cajal (the gut pacemaker cells), together with myenteric and submucosal ganglion and glial cells, in patients with diverticulosis. PATIENTS: Full thickness colonic samples were obtained from 39 patients undergoing surgery for diverticulosis. Specimens from tumour free areas of the colon in 10 age matched subjects undergoing surgery for colorectal cancer served as controls.
methodsInterstitial cells of Cajal were assessed using anti-Kit antibodies; submucosal and myenteric plexus neurones and glial cells were assessed by means of anti-PGP 9.5 and anti-S-100 monoclonal antibodies, respectively.
resultsPatients with diverticulosis had normal numbers of myenteric and submucosal plexus neurones compared with controls (p = 0.103 and p = 0.516, respectively). All subtypes of interstitial cells of Cajal were significantly (p = 0.0003) reduced compared with controls, as were glial cells (p = 0.0041).
conclusionsInterstitial cells of Cajal and glial cells are decreased in colonic diverticular disease, whereas enteric neurones appear to be normally represented. This finding might explain some of the large bowel motor abnormalities reported to occur in this condition.
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Registered trials
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