ArticleBiophysical journal2005
Flexible charged macromolecules on mixed fluid lipid membranes: theory and Monte Carlo simulations.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 63 citations in OpenAlex.
- Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes.Angewandte Chemie (International ed. in English) · 2022Review
- Heterogeneity in Lateral Distribution of Polycations at the Surface of Lipid Membrane: From the Experimental Data to the Theoretical Model.Materials (Basel, Switzerland) · 2021Review
- Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Article
- Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model.European biophysics journal : EBJ · 2014Article
- Compositional redistribution and dynamic heterogeneity in mixed lipid membrane induced by polyelectrolyte adsorption: effects of chain rigidity.The European physical journal. E, Soft matter · 2014Article
- Lateral dynamics of proteins with polybasic domain on anionic membranes: a dynamic Monte-Carlo study.Biophysical journal · 2011Article
- Adsorption of proteins on a lipid bilayer.European biophysics journal : EBJ · 2010Article
- Stability of protein-decorated mixed lipid membranes: The interplay of lipid-lipid, lipid-protein, and protein-protein interactions.The Journal of chemical physics · 2009Article
- The "electrostatic-switch" mechanism: Monte Carlo study of MARCKS-membrane interaction.Biophysical journal · 2008Article
- Debye-Hückel theory of mixed charged-zwitterionic lipid layers.The European physical journal. E, Soft matter · 2008Article
- Colloid adsorption onto responsive membranes.Biophysical journal · 2008Article
- Protein diffusion on charged membranes: a dynamic mean-field model describes time evolution and lipid reorganization.Biophysical journal · 2008Article
- Monte Carlo simulations of tBid association with the mitochondrial outer membrane.European biophysics journal : EBJ · 2007Article
- Membrane-bound basic peptides sequester multivalent (PIP2), but not monovalent (PS), acidic lipids.Biophysical journal · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluid membranes containing charged lipids enhance binding of oppositely charged proteins by mobilizing these lipids into the interaction zone, overcoming the concomitant entropic losses due to lipid segregation and lower conformational freedom upon macromolecule adsorption. We study this energetic-entropic interplay using Monte Carlo simulations and theory. Our model system consists of a flexible cationic polyelectrolyte, interacting, via Debye-Hückel and short-ranged repulsive potentials, with membranes containing neutral lipids, 1% tetravalent, and 10% (or 1%) monovalent anionic lipids. Adsorption onto a fluid membrane is invariably stronger than to an equally charged frozen or uniform membrane. Although monovalent lipids may suffice for binding rigid macromolecules, polyvalent counter-lipids (e.g., phosphatidylinositol 4,5 bisphosphate), whose entropy loss upon localization is negligible, are crucial for binding flexible macromolecules, which lose conformational entropy upon adsorption. Extending Rosenbluth's Monte Carlo scheme we directly simulate polymer adsorption on fluid membranes. Yet, we argue that similar information could be derived from a biased superposition of quenched membrane simulations. Using a simple cell model we account for surface concentration effects, and show that the average adsorption probabilities on annealed and quenched membranes coincide at vanishing surface concentrations. We discuss the relevance of our model to the electrostatic-switch mechanism of, e.g., the myristoylated alanine-rich C kinase substrate protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.