ArticleAmerican journal of physiology. Heart and circulatory physiology2006
Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venules.
Article in American journal of physiology. Heart and circulatory physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 45 citations in OpenAlex.
- Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026Review
- Liposomal nanocarriers of preassembled glycocalyx restore normal venular permeability and shear stress sensitivity in sepsis: assessed quantitatively with a novel microchamber system.American journal of physiology. Heart and circulatory physiology · 2024Article
- Anti-Inflammatory Effects of the Iron Chelator, DIBI, in Experimental Acute Lung Injury.Molecules (Basel, Switzerland) · 2022Article
- Leveraging avidin-biotin interaction to quantify permeability property of microvessels-on-a-chip networks.American journal of physiology. Heart and circulatory physiology · 2022Article
- VEGF signalling enhances lesion burden in KRIT1 deficient mice.Journal of cellular and molecular medicine · 2020Article
- Sex differences influencing micro- and macrovascular endothelial phenotype in vitro.The Journal of physiology · 2018Article
- Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.Scientific reports · 2017Article
- Article
- Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery.Journal of visualized experiments : JoVE · 2015Article
- KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.The Journal of biological chemistry · 2014Article
- Permeability and contractile responses of collecting lymphatic vessels elicited by atrial and brain natriuretic peptides.The Journal of physiology · 2013Article
- Diabetes mellitus and periodontal diseases.Current diabetes reports · 2013Review
- The microcirculation in adipose tissue inflammation.Reviews in endocrine & metabolic disorders · 2013Review
- High-resolution structural and functional assessments of cerebral microvasculature using 3D Gas ΔR2*-mMRA.PloS one · 2013Article
- Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Local oxidative and nitrosative stress increases in the microcirculation during leukocytes-endothelial cell interactions.PloS one · 2012Article
- Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1.American journal of physiology. Cell physiology · 2011Article
- Lymphatic fluid: exchange mechanisms and regulation.The Journal of physiology · 2011Article
- Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury.PloS one · 2011Article
- Type 1 diabetes predisposes to enhanced gingival leukocyte margination and macromolecule extravasation in vivo.Journal of periodontal research · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In microvessels, acute inflammation is typified by an increase in leukocyte-endothelial cell interactions, culminating in leukocyte transmigration into the tissue, and increased permeability to water and solutes, resulting in tissue edema. The goal of this study was to establish a method to quantify solute permeability (P(s)) changes in microvessels in intact predominantly blood-perfused networks in which leukocyte transmigratory behavior could be precisely described using established paradigms. We used intravital confocal microscopy to measure solute (BSA) flux across microvessel walls, hence P(s). A quantitative fluorescence approach (Huxley VH, Curry FE, and Adamson RH. Am J Physiol Heart Circ Physiol 252: H188-H197, 1987) was adapted to the imaged confocal tissue slice in which the fluorescent source volume and source surface area of the microvessel were restricted to the region of vessel that was contained within the imaged confocal tissue section. P(s) measurements were made in intact cremaster muscle microvasculature of anesthetized mice and compared with measurements of P(s) made in isolated rat skeletal muscle microvessels. Mouse arteriolar P(s) was 9.9 +/- 1.1 x 10(-7) cm/s (n = 16), which was not different from 8.4 +/- 1.3 x 10(-7) cm/s (n = 6) in rat arterioles. Values in venules were significantly (P < 0.05) higher: 44.4 +/- 7.9 x 10(-7) cm/s (n = 14) in mice and 25.0 +/- 3.7 x 10(-7) cm/s in rats. Convective coupling was estimated to contribute <10% to the measured P(s) in both microvessel types and both animal models. We conclude that this approach provides an appropriate quantification of P(s) in the intact microvasculature and that arteriolar P(s), while lower than in venules, is nevertheless consistent with arterioles being a significant source of interstitial protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.