Evidence map›Paper›PMID 16126791›Full record

GuidelineAnnals of the rheumatic diseases2006

ASAS/EULAR recommendations for the management of ankylosing spondylitis.

J Zochling, D van der Heijde, R Burgos-Vargas, E Collantes, J C Davis, B Dijkmans, M Dougados, P Géher, R D Inman, M A Khan and 14 more

4 registry-linked trialsAbstract readPractice Guideline
In one paragraph

Guideline in Annals of the rheumatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 199 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00432653 phase2 / phase3unknown statusnot on this mapstarted 2007, after this paper: background citation

Open Label Clinical Trial With Rituximab (MabThera ®) in Ankylosing Spondylitis

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2007 to 2009Enrolled20ConditionsAnkylosing SpondylitisArmsrituximab
NCT00558506 phase2unknown statusnot on this mapstarted 2008, after this paper: background citation

Pilot Open Label Clinical Trial With Abatacept in Ankylosing Spondylitis

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2008 to 2009Enrolled30ConditionsAnkylosing SpondylitisArmsabatacept
NCT01286545 unknown statusnot on this mapstarted 2011, after this paper: background citation

European Ankylosing Spondylitis Infliximab Cohort (EASIC) Follow up Registration Study

TypeobservationalSponsorRheumazentrum RuhrgebietRan2011 to 2013Enrolled100ConditionsAnkylosing Spondylitis
NCT05703932 nacompletednot on this mapstarted 2023, after this paper: background citation

Examining the Effect of Home-Based Exercise on Disease Activity in Patients With Ankylosing Spondylitis Using SIRI (Systemic Inflammatory Response Index) and SII (Systemic Inflammation Index): A Randomized Controlled Trial

TypeinterventionalSponsorBakirkoy Dr. Sadi Konuk Research and Training HospitalRan2023 to 2024Enrolled64ConditionsAnkylosing SpondylitisArmshome-based exercises
3 · Its place in the literature

Who cites it

199 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Treatment recommendations for psoriatic arthritis.Annals of the rheumatic diseases · 2009
    Guideline
  7. Physiotherapy interventions for ankylosing spondylitis.The Cochrane database of systematic reviews · 2008
    Pooled it
  8. Guideline
  9. Pooled it
  10. Pooled it
  11. Trial
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  13. Trial
  14. Clinical Efficacy of Modified Yanghe Decoction in Ankylosing Spondylitis: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
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  20. Trial

139 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

J ZochlingRheumazentrum-Ruhrgebiet, St Josefs-Krankenhaus, Landgrafenstr 15, 44652 Herne, Germany.
D van der Heijde
R Burgos-Vargas
E Collantes
J C Davis
B Dijkmans
M Dougados
P Géher
R D Inman
M A Khan
T K Kvien
M Leirisalo-Repo
I Olivieri
K Pavelka
J Sieper
G Stucki
R D Sturrock
S van der Linden
D Wendling
H Böhm
B J van Royen
J Braun
'ASsessment in AS' international working group
European League Against Rheumatism

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo develop evidence based recommendations for the management of ankylosing spondylitis (AS) as a combined effort of the 'ASsessment in AS' international working group and the European League Against Rheumatism.

methodsEach of the 22 participants was asked to contribute up to 15 propositions describing key clinical aspects of AS management. A Delphi process was used to select 10 final propositions. A systematic literature search was then performed to obtain scientific evidence for each proposition. Outcome data for efficacy, adverse effects, and cost effectiveness were abstracted. The effect size, relative risk, number needed to treat, and incremental cost effectiveness ratio were calculated. On the basis of the search results, 10 major recommendations for the management of AS were constructed. The strength of recommendation was assessed based on the strength of the literature evidence, risk-benefit trade-off, and clinical expertise.

resultsThe final recommendations considered the use of non-steroidal anti-inflammatory drugs (NSAIDs) (conventional NSAIDs, coxibs, and co-prescription of gastroprotective agents), disease modifying antirheumatic drugs, treatments with biological agents, simple analgesics, local and systemic steroids, non-pharmacological treatment (including education, exercise, and physiotherapy), and surgical interventions. Three general recommendations were also included. Research evidence (categories I-IV) supported 11 interventions in the treatment of AS. Strength of recommendation varied, depending on the category of evidence and expert opinion.

conclusionTen key recommendations for the treatment of AS were developed and assessed using a combination of research based evidence and expert consensus. Regular updating will be carried out to keep abreast of new developments in the management of AS.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalAntirheumatic AgentsArthroplasty, Replacement, HipCost-Benefit AnalysisEvidence-Based MedicineExerciseHumansInternational CooperationPhysical Therapy ModalitiesSpondylitis, AnkylosingTreatment OutcomeTumor Necrosis Factor-alphaAnti-Inflammatory Agents, Non-SteroidalAntirheumatic AgentsTumor Necrosis Factor-alpha

Identifiers

PMID16126791
PMCPMC1798102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.