ArticleThe Journal of biological chemistry2005
Cadherins mediate both the association between PS1 and beta-catenin and the effects of PS1 on beta-catenin stability.
Article in The Journal of biological chemistry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Rare A360T Mutation Alters GSK3β(Ser9) Binding in the Cytosolic Loop of Presenilin 1, Influencing β-Catenin Nuclear Localization and Pro-Death Gene Expression in Alzheimer's Disease Case.International journal of molecular sciences · 2023Article
- p120 catenin recruits HPV to γ-secretase to promote virus infection.PLoS pathogens · 2020Article
- New Lipid Mediators in Retinal Angiogenesis and Retinopathy.Frontiers in pharmacology · 2019Review
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- Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.The Journal of biological chemistry · 2013Article
- The way Wnt works: components and mechanism.Growth factors (Chur, Switzerland) · 2013Review
- Presenilin1 regulates histamine neuron development and behavior in zebrafish, danio rerio.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Wnt/beta-catenin signaling and small molecule inhibitors.Current pharmaceutical design · 2013Review
- Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.Progress in neurobiology · 2012Review
- Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference.International journal of Alzheimer's disease · 2011Article
- Review: disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias.American journal of Alzheimer's disease and other dementias · 2010Review
- Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density.Journal of Alzheimer's disease : JAD · 2010Article
- Presenilin: RIP and beyond.Seminars in cell & developmental biology · 2009Review
- Toward structural elucidation of the gamma-secretase complex.Structure (London, England : 1993) · 2009Review
- p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.The Journal of biological chemistry · 2009Article
- Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity.PloS one · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Presenilin1 (PS1), a protein involved in cellular development, forms functional complexes with beta-catenin, a regulator of Wnt signaling and cell-cell adhesion. In addition, both proteins have been shown to play important roles in disease including cancer and Alzheimer disease. Although PS1 and beta-catenin are found in the same complexes, it is not clear whether they bind directly to each other or a third complex component, like cadherin, may mediate their interactions. Here we show that PS1 and beta-catenin form no detectable complexes in cells that express no cadherin. In contrast, these complexes are readily found in E-cadherin containing cells. Furthermore, binding of both PS1 and beta-catenin to E-cadherin is necessary for the formation of PS1/beta-catenin complexes. Importantly, our data show that binding of PS1 to cadherin mediates the effects of PS1 on the phosphorylation, ubiquitination, and destabilization of beta-catenin. Thus, cadherins mediate both the association of PS1 and beta-catenin and the effects of PS1 on the cellular levels of beta-catenin.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.