ReviewOncogene2005
TGF-beta signaling in T cells: roles in lymphoid and epithelial neoplasia.
Review in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 79 citations in OpenAlex.
- Take a Walk to the Wild Side ofMicrobiology and molecular biology reviews : MMBR · 2021Review
- Immunostimulatory silica nanoparticle boosts innate immunity in brain tumors.Nanoscale horizons · 2021Article
- FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration.Frontiers in cell and developmental biology · 2020Article
- The many talents of transforming growth factor-β in the kidney.Current opinion in nephrology and hypertension · 2019Review
- Zfyve16 regulates the proliferation of B-lymphoid cells.Frontiers of medicine · 2018Article
- TGF-β Family Signaling in Tumor Suppression and Cancer Progression.Cold Spring Harbor perspectives in biology · 2017Review
- Transforming growth factor-β1 functional polymorphisms in myeloablative sibling hematopoietic stem cell transplantation.Bone marrow transplantation · 2017Article
- TGFΒ-induced transcription in cancer.Seminars in cancer biology · 2017Review
- Betulinic acid enhances TGF-β signaling by altering TGF-β receptors partitioning between lipid-raft/caveolae and non-caveolae membrane microdomains in mink lung epithelial cells.Journal of biomedical science · 2016Article
- The diverse roles of the TNF axis in cancer progression and metastasis.Trends in cancer research · 2016Article
- TGF-β signaling and its role in the regulation of hematopoietic stem cells.Systems and synthetic biology · 2015Review
- The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.Genes and immunity · 2013Article
- Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling.FEMS immunology and medical microbiology · 2012Article
- Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice.The Journal of clinical investigation · 2011Article
- Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.PLoS genetics · 2010Article
- SMAD4 is required for development of maximal endotoxin tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
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- Cancer immunotherapy: the role regulatory T cells play and what can be done to overcome their inhibitory effects.Current molecular medicine · 2009Review
- TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.Gastroenterology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor-beta (TGF-beta) plays an essential role in regulating the homeostasis of cells in the lymphoid lineage. TGF-beta signaling is not required for normal thymopoiesis, but is essential for regulating the expansion, activation, and effector function of the mature CD4+ and CD8+ T cells in the peripheral lymphoid organs and target tissues. Recent studies in both mice and humans have elucidated an important and complex role for TGF-beta in regulatory T-cell biology. Disruption of TGF-beta signaling in T cells impairs the maintenance of regulatory T cells, results in the expansion of activated effector T cells, and is associated with the production of cytokines that have major effects on cells in their environment. While autoimmunity and inflammation are the principal phenotypes associated with the abrogation of TGF-beta signaling in T cells in mice, emerging evidence now also directly links Smad-dependent TGF-beta signaling in T cells to the suppression of epithelial neoplasia. The TGF-beta receptor-activated Smad3 plays a critical role in mediating many of the inhibitory effects of TGF-beta signaling in T cells, and has now been established as an important suppressor of leukemogenesis. These studies are increasing our awareness of the many complex mechanisms through which TGF-beta signaling controls the pathogenesis of cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.