ArticleProceedings of the National Academy of Sciences of the United States of America2005
Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.PloS one · 2015Pooled it
- Frequency Evaluation of theInternational journal of molecular sciences · 2023Article
- An HIV elite controller patient carrying the homozygous H63D variant in the homeostatic iron regulator gene: A case report.Medicine · 2021Article
- Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species.Immunogenetics · 2018Article
- The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system.Immunity, inflammation and disease · 2017Review
- Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?Frontiers in immunology · 2017Review
- The role of MHC class Ib-restricted T cells during infection.Immunogenetics · 2016Review
- The burgeoning family of unconventional T cells.Nature immunology · 2015Review
- An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection.PLoS genetics · 2014Article
- Immune parameters to consider when choosing T-cell receptors for therapy.Frontiers in immunology · 2013Article
- Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis.International journal of cancer · 2011Article
- Molecular identification of an MHC-independent ligand recognized by a human {alpha}/{beta} T-cell receptor.Blood · 2011Article
- The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors.Journal of biomedicine & biotechnology · 2010Review
- Function of the hemochromatosis protein HFE: Lessons from animal models.World journal of gastroenterology · 2008Article
- Characterization of a novel nonclassical T cell clone with broad reactivity against human renal cell carcinomas.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cis interactions of immunoreceptors with MHC and non-MHC ligands.Nature reviews. Immunology · 2008Review
- The unfolded protein response in hereditary haemochromatosis.Journal of cellular and molecular medicine · 2008Review
- The Tritope Model for restrictive recognition of antigen by T-cells II. Implications for ontogeny, evolution and physiology.Molecular immunology · 2008Review
- TCR-MHC docking orientation: natural selection, or thymic selection?Immunologic research · 2008Review
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17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crystallographic analysis of human Hfe has documented an overall structure similar to classical (class Ia) MHC molecules with a peptide binding groove deprived of ligand. Thus, to address the question of whether alphabeta T cells could recognize MHC molecules independently of bound ligands, we studied human and mouse Hfe interactions with T lymphocytes. We provide formal evidence of direct cytolytic recognition of human Hfe by mouse alphabeta T cell receptors (TCR) in HLA-A*0201 transgenic mice and that this interaction results in ZAP-70 phosphorylation. Furthermore, direct recognition of mouse Hfe molecules by cytotoxic T lymphocytes (CTLs) was demonstrated in DBA/2 Hfe knockout mice. These CTLs express predominantly two T cell antigen receptor alpha variable gene segments (AV6.1 and AV6.6). Interestingly, in wild-type mice we identified a subset of CD8+ T cells positively selected by Hfe that expresses the AV6.1/AV6.6 gene segments. T cell antigen receptor recognition of MHC molecules independently of bound ligand has potential general implications in alloreactivity and identifies in the Hfe case a cognitive link supporting the concept that the immune system could be involved in the control of iron metabolism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.