ArticleThe Journal of physiology2005
Dual Ca2+ modulation of glycinergic synaptic currents in rodent hypoglossal motoneurones.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- The Cannabinoid CBInternational journal of molecular sciences · 2025Article
- Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons.Frontiers in cellular neuroscience · 2019Article
- Wired for eating: how is an active feeding circuitry established in the postnatal brain?Current opinion in neurobiology · 2018Review
- Developmental Changes in the Inhibition of Glycinergic Synaptic Currents by Niflumic Acid in Hypoglossal Motoneurons.Frontiers in molecular neuroscience · 2018Article
- Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats.Sleep · 2017Article
- Intracerebroventricular injections of dronabinol, a cannabinoid receptor agonist, does not attenuate serotonin-induced apnea in Sprague-Dawley rats.Journal of negative results in biomedicine · 2016Article
- Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses.Pharmacological research · 2015Review
- Long-term potentiation of glycinergic synapses triggered by interleukin 1β.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- Identification of a pharmacological target for genioglossus reactivation throughout sleep.Sleep · 2014Article
- Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.Experimental neurology · 2013Review
- Triphasic blood pressure responses to cannabinoids: do we understand the mechanism?British journal of pharmacology · 2012Review
- Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C.The EMBO journal · 2011Article
- Frequency-Dependent Cannabinoid Receptor-Independent Modulation of Glycine Receptors by Endocannabinoid 2-AG.Frontiers in molecular neuroscience · 2011Article
- Involvement of central beta2-adrenergic, NMDA and thromboxane A2 receptors in the pressor effect of anandamide in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstem.Journal of neurophysiology · 2009Article
- Endocannabinoid signalling triggered by NMDA receptor-mediated calcium entry into rat hippocampal neurons.The Journal of physiology · 2007Article
- Endocannabinoids in the dentate gyrus.Progress in brain research · 2007Review
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycinergic synapses are implicated in the coordination of reflex responses, sensory signal processing and pain sensation. Their activity is pre- and postsynaptically regulated, although mechanisms are poorly understood. Using patch-clamp recording and Ca2+ imaging in hypoglossal motoneurones from rat and mouse brainstem slices, we address here the role of cytoplasmic Ca2+ (Ca(i)) in glycinergic synapse modulation. Ca2+ influx through voltage-gated or NMDA receptor channels caused powerful transient inhibition of glycinergic IPSCs. This effect was accompanied by an increase in both the failure rate and paired-pulse ratio, as well as a decrease in the frequency of mIPSCs, suggesting a presynaptic mechanism of depression. Inhibition was reduced by the cannabinoid receptor antagonist SR141716A and occluded by the agonist WIN55,212-2, indicating involvement of endocannabinoid retrograde signalling. Conversely, in the presence of SR141716A, glycinergic IPSCs were potentiated postsynaptically by glutamate or NMDA, displaying a Ca2(+)-dependent increase in amplitude and decay prolongation. Both presynaptic inhibition and postsynaptic potentiation were completely prevented by strong Ca(i) buffering (20 mm BAPTA). Our findings demonstrate two independent mechanisms by which Ca2+ modulates glycinergic synaptic transmission: (i) presynaptic inhibition of glycine release and (ii) postsynaptic potentiation of GlyR-mediated responses. This dual Ca2(+)-induced regulation might be important for feedback control of neurotransmission in a variety of glycinergic networks in mammalian nervous systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.