ArticleDevelopmental biology2005
Development and sensitivity to serotonin of Drosophila serotonergic varicosities in the central nervous system.
Article in Developmental biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Partners in plasticity: serotonergic glial interactions in brain circuit remodeling.Frontiers in neuroscience · 2026Review
- Serotonin functions as a bidirectional guidance molecule regulating growth cone motility.Cellular and molecular life sciences : CMLS · 2021Article
- Bitbow Enables Highly Efficient Neuronal Lineage Tracing and Morphology Reconstruction in SingleFrontiers in neural circuits · 2021Article
- Idiosyncratic neural coding and neuromodulation of olfactory individuality inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Characterization of Drosophila octopamine receptor neuronal expression using MiMIC-converted Gal4 lines.The Journal of comparative neurology · 2020Article
- Studying the Contribution of Serotonin to Neurodevelopmental Disorders. Can This Fly?Frontiers in behavioral neuroscience · 2020Review
- A Plastic Visual Pathway Regulates Cooperative Behavior in Drosophila Larvae.Current biology : CB · 2019Article
- Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae.PloS one · 2017Article
- Development of the Neurochemical Architecture of the Central Complex.Frontiers in behavioral neuroscience · 2016Review
- Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.Neural plasticity · 2016Article
- Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.Neurochemistry international · 2014Review
- Serotonin and downstream leucokinin neurons modulate larval turning behavior in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Functional analysis of the larval feeding circuit in Drosophila.Journal of visualized experiments : JoVE · 2013Article
- Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster.Genetics · 2013Article
- The serotonergic central nervous system of the Drosophila larva: anatomy and behavioral function.PloS one · 2012Article
- Ontogeny and regulation of the serotonin transporter: providing insights into human disorders.Pharmacology & therapeutics · 2011Review
- Analysis of biogenic amines in a single Drosophila larva brain by capillary electrophoresis with fast-scan cyclic voltammetry detection.Analytical chemistry · 2011Article
- Patterns of dye coupling involving serotonergic neurons provide insights into the cellular organization of a central complex lineage of the embryonic grasshopper Schistocerca gregaria.Development genes and evolution · 2011Article
- Serotonin: a regulator of neuronal morphology and circuitry.Trends in neurosciences · 2010Review
- Serotonergic dystrophy induced by excess serotonin.Molecular and cellular neurosciences · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Serotonin is a classical small-molecule neurotransmitter with known effects on developmental processes. Previous studies have shown a developmental role for serotonin in the fly peripheral nervous system. In this study, we show that serotonin can modulate the development of serotonergic varicosities within the fly central nervous system. We have developed a system to examine the development of serotonergic varicosities in the larval CNS. We use this method to describe the normal serotonergic development in the A7 abdominal ganglion. From first to third instar larvae, the volume of the neuropil and number of serotonergic varicosities increase substantially while the varicosity density remains relatively constant. We hypothesize that serotonin is an autoregulator for serotonergic varicosity density. We tested the sensitivity of serotonergic varicosities to serotonin by adding neurotransmitter at various stages to isolated larval ventral nerve cords. Addition of excess exogenous serotonin decreases native varicosity density in older larvae, and these acute effects are reversible. The effects of serotonin appear to be selective for serotonergic varicosities, as dopaminergic and corazonergic varicosities remain qualitatively intact following serotonin application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.